271242-70-7

Basic information

• Product Name: N,N-dimethyl-4-{[(4-nitrophenyl)amino]methyl}aniline
• Synonyms: N,N-dimethyl-4-{[(4-nitrophenyl)amino]methyl}aniline
• CAS NO: 271242-70-7
• Molecular Weight: 271.319
• Mol File: 271242-70-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-4-{[(4-nitrophenyl)amino]methyl}aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-4-{[(4-nitrophenyl)amino]methyl}aniline(271242-70-7)
• EPA Substance Registry System: N,N-dimethyl-4-{[(4-nitrophenyl)amino]methyl}aniline(271242-70-7)

Safety Data

• Hazardous Substances Data: 271242-70-7(Hazardous Substances Data)

Upstream product

• 19293-58-4 (4-aminomethylphenyl)dimethylamine 
• 350-46-9 4-Fluoronitrobenzene 
• 896-05-9 N,N-dimethyl-4-((4-nitrophenylimino)methyl)aniline 

Downstream Products

• 5711-79-5 N-{[4-(dimethylamino)phenyl]methyl}benzene-1,4-diamine 

Relevant articles and documents

Novel quinazoline derivative LU1506, preparation method and applications thereof

The invention discloses a novel quinazoline derivative LU1506 and a preparation method thereof. The derivative is chemically named as N-{[(4-dimethylamino)phenyl]methyl}-4-N-[7-methoxyl-6-(2-pyrrolidyl)hydroxyethyl]quinazoline-4-yl}benzene-1,4-diamine. The provided quinazoline derivative, pharmaceutically acceptable salts, solvates, and hydrates thereof have an excellent in-vitro/in-vivo antitumor activity on MCF-7, SK-BR-3, MDA-MB-468, U-118 MG, HTC116, and U-87 MG, and can be used to prepare antitumor drugs.

Polymethylhydrosiloxane (PMHS)/trifluoroacetic acid (TFA): a novel system for reductive amination reactions

Polymethylhydrosiloxane (PMHS)/trifluoroacetic acid (TFA) was discovered as a novel metal-free system for reductive amination reactions. A variety of (het)aryl amines as well as a representative carbamate and urea were successfully alkylated by benzaldehyde in the presence of PMHS and TFA in dichloromethane at room temperature in moderate to excellent yields (28-87%). Furthermore, this reaction protocol was successfully applied to the alkylation of p-nitroaniline with a wide range of aldehydes, ketones, and a representative acetal to obtain the alkylated products in yields ranging from 40% to 92%. The current work represents one of the very few examples of PMHS being activated by a Br?nsted acid.