27127-09-9Relevant articles and documents
Synthesis and characterizaton of monoaminophosphine, bis(amino)phosphine derivatives, and their metal complexes
Sarioez, Oezlem,Oeznergiz, Sena
experimental part, p. 698 - 703 (2011/09/16)
Functionalized monoaminophosphine of the type Ph2PNR2 (1 and 3) and bis(amino)phosphine of the type PhP(NR2)2 (2) have been synthesized by treating Ph2PCl or PhPCl2 with corresponding amine
Regio- and diastereoselective preparation of tetrahydrobenzo[c]-1-aza-2lambda(5)-phospholes through dearomatization cyclization of lithiated N-benzyl-N-alkyl(diphenyl)phosphinamides. Synthesis of gamma-(N-alkylamino)phosphinic acids.
Fernandez, Ignacio,Ortiz, Fernando Lopez,Velazquez, Amador Menendez,Granda, Santiago Garcia
, p. 3852 - 3860 (2007/10/03)
A study of the protonation of the cycloadducts derived from the dearomatization reaction of lithiated N-alkyl-N-benzyldiphenylphosphinamides has been carried out. The regio- and stereoselectivity of the process has been analyzed in terms of the size of the N-alkyl substituent, the acidity and size of the protonating reagent, and the cosolvent used. The optimization of these variables allowed the preparation of tetrahydrobenzo[c]-1-aza-2lambda(5)-phospholes containing a 1,3-cyclohexadiene or 1,4-cyclohexadiene system with moderate to excellent regio- and stereocontrol. The heterocycles were readily hydrolyzed, affording gamma-(N-alkylamino)diphenylphosphinic acids with the functionalities linked to a cyclohexadiene substructure.