2713-29-3

Basic information

• Product Name: 4-Fluoro-2-iodophenol
• Synonyms: 4-Fluoro-2-iodophenol;4-Fluoro-1-hydroxy-2-iodobenzene;2-Iodo-4-fluorophenol;5-Fluoro-2-hydroxyiodobenzene;4-Fluoro-2-iodophenol 95%;4-Fluoro-2-iodophenol95%
• CAS NO: 2713-29-3
• Molecular Formula: C₆H₄FIO
• Molecular Weight: 237.9982332
• Mol File: 2713-29-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 120-123℃
• Boiling Point: 196℃
• Flash Point: 73℃
• Appearance: /
• Density: 2.085
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.53±0.18(Predicted)
• CAS DataBase Reference: 4-Fluoro-2-iodophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-2-iodophenol(2713-29-3)
• EPA Substance Registry System: 4-Fluoro-2-iodophenol(2713-29-3)

Safety Data

• Hazardous Substances Data: 2713-29-3(Hazardous Substances Data)

Usage

General Description

4-Fluoro-2-iodophenol is a chemical compound with the molecular formula C6H4FIO. It is a yellow solid with a melting point of 58-60°C and a boiling point of 278-281°C. 4-Fluoro-2-iodophenol is used in the synthesis of pharmaceuticals, dyes, and organic compounds. It is also used as a reagent in organic chemistry reactions. 4-Fluoro-2-iodophenol is considered to be a hazardous substance and should be handled with care due to its toxic and irritating properties.

Upstream product

• 371-41-5 4-Fluorophenol 
• 445-83-0 4-fluoro-1-methoxy-2-nitrobenzene 
• 1978-39-8 5-fluoro-2-methoxy-aniline 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 199585-10-9 C₁₀H₁₂FNO₂ 
• 3824-22-4 4-fluoro-2-iodo-1-methoxybenzene 

Downstream Products

• 451-91-2 (4-fluoro-2-iodo-phenoxy)-acetic acid 
• 1381964-92-6 5-fluoro-2-phenylbenzo[b]furan 
• 1352954-90-5 C₂₁H₁₄FNO₄ 
• 1352954-95-0 C₁₄H₉FO 
• 65540-47-8 5-fluoro-2-(4'-methoxyphenyl)benzo[b]furan 
• 5839-56-5 5-fluoro-2,3-bis(4-methoxyphenyl)benzofuran 

Relevant articles and documents

Metal-ligand complexes having electron withdrawing group, catalyst composition for ethylene-based polymerization containing the same, and production methods of ethylene-based polymers using the same

A metal - ligand complex having a strong electron donor group and an electron withdrawing group at the same time. The present invention relates to a catalyst composition for ethylene polymerization and a method for preparing an ethylene-based polymer usin

Pd-Catalyzed ipso, meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biologically and pharmacologically active compounds.

Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols

An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide as a cheap iodine atom source. A totally controlled monoiodination was achieved by buffering the reaction medium with K3PO4. This protocol proceeds with short reaction times, at mild temperatures, in an open flask, and generally with high yields. Gram-scale reactions, as well as the scope of this protocol, were explored with electron-rich and electron-poor phenols as well as heterocycles. Quantum chemistry calculations revealed PhII(OH)·NH3 to be the most plausible iodinating active species as a reactive "I+" synthon. In light of the relevance of the iodoarene moiety, we present herein a practical, efficient, and simple procedure with a broad functional group scope that allows access to the iodoarene core unit.