2713-29-3

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Fluoro-2-iodophenol is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Dye Production:
In the dye industry, 4-Fluoro-2-iodophenol is utilized as a precursor in the production of dyes, where its chemical structure allows for the creation of a range of colorants with unique characteristics.
Used in Organic Compounds Synthesis:
4-Fluoro-2-iodophenol serves as a building block in the synthesis of various organic compounds, contributing to the formation of complex molecules with diverse applications in different fields.
Used as a Reagent in Organic Chemistry Reactions:
4-Fluoro-2-iodophenol is employed as a reagent in organic chemistry, facilitating specific types of reactions that may not be possible with other compounds, thus broadening the scope of chemical synthesis.
Safety Considerations:
Due to its hazardous nature, 4-Fluoro-2-iodophenol should be handled with care, employing appropriate safety measures to mitigate the risks associated with its toxic and irritating properties.

Upstream product

• 3824-22-4 4-fluoro-2-iodo-1-methoxybenzene 
• 371-41-5 4-Fluorophenol 
• 199585-10-9 C₁₀H₁₂FNO₂ 
• 445-83-0 4-fluoro-1-methoxy-2-nitrobenzene 
• 1978-39-8 5-fluoro-2-methoxy-aniline 
• 459-60-9 1-fluoro-4-methoxybenzene 

Downstream Products

• 200956-97-4 C₁₃H₁₀FIO 
• 1242169-07-8 C₁₉H₁₃FN₂O 
• 1190299-36-5 (E)-3-(5-fluoro-2-hydroxyphenyl)acrylaldehyde 
• 1381964-92-6 5-fluoro-2-phenylbenzo[b]furan 
• 1352954-90-5 C₂₁H₁₄FNO₄ 
• 1352954-95-0 C₁₄H₉FO 
• 1453207-30-1 (6-fluoro-2-(4-methoxyphenyl)benzofuran-3-yl)(phenyl)methanone 
• 1453207-36-7 5-fluoro-2-phenylbenzofuran-3-carbonitrile 
• 1610337-84-2 4-fluoro-2-(1H-indol-1-yl)phenol 
• 1610337-69-3 (E)-ethyl 3-(1-(5-fluoro-2-hydroxyphenyl)-1H-indol-2-yl)acrylate 

Relevant academic research and scientific papers

Metal-ligand complexes having electron withdrawing group, catalyst composition for ethylene-based polymerization containing the same, and production methods of ethylene-based polymers using the same

A metal - ligand complex having a strong electron donor group and an electron withdrawing group at the same time. The present invention relates to a catalyst composition for ethylene polymerization and a method for preparing an ethylene-based polymer usin

Biomimetic carbene cascades enabled imine derivative migration from carbene -bearing thiocarbamates

Inspired by the body circulation of Omeprazole (irreversible proton pump inhibitor), we disclose the carbene-triggered cascades for the synthesis of 2-aminobenzofuran derivatives from N-sulfonyl-1,2,3-triazoles or benzothioazole-bearing thiocarbamates, which represents an unprecedented imine derivative migration process. Furthermore, the desulfurizing reagent-free Barton-Kellogg-type reactions starting from N-sulfonyl-1,2,3-triazoles have also been achieved for the first time, and elemental sulfur is confirmed as a byproduct during this transformation. Both experimental data and DFT calculations further thoroughly explained the unique reactivity.

Pd-Catalyzed ipso, meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biologically and pharmacologically active compounds.

Entry to 1,2,3,4-Tetrasubstituted Arenes through Addressing the " Meta Constraint" in the Palladium/Norbornene Catalysis

Arenes with four different contiguous substituents, i.e. 1,2,3,4-tetrasubstituted arenes, are commonly found in bioactive compounds, but they are nontrivial to access via conventional methods. Through addressing the "meta constraint" in the palladium/norbornene (Pd/NBE) cooperative catalysis, which is the difficulty of tolerating a sizable meta substituent in aryl halide substrates, here a modular and regioselective approach is realized for preparing 1,2,3,4-tetrasubstituted arenes. One key is the use of a C2-amide-substituted NBE, and a combined experimental and computational study reveals its role in promoting the NBE insertion and the ortho C-H metalation steps. The scope is broad: A variety of electrophiles and nucleophiles could be introduced to the ortho and ipso positions, respectively, with 1,4-disubstituted aryl halides, leading to diverse unsymmetrical contiguous tetrasubstituted arenes. Application of this approach has been demonstrated in streamlined syntheses of several bioactive compounds.

Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols

An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide as a cheap iodine atom source. A totally controlled monoiodination was achieved by buffering the reaction medium with K3PO4. This protocol proceeds with short reaction times, at mild temperatures, in an open flask, and generally with high yields. Gram-scale reactions, as well as the scope of this protocol, were explored with electron-rich and electron-poor phenols as well as heterocycles. Quantum chemistry calculations revealed PhII(OH)·NH3 to be the most plausible iodinating active species as a reactive "I+" synthon. In light of the relevance of the iodoarene moiety, we present herein a practical, efficient, and simple procedure with a broad functional group scope that allows access to the iodoarene core unit.

Synthesis of 8-azaprotosappanin A derivatives via intramolecular palladium-catalyzed ortho C-H activation/C-C cyclization and their antibacterial activity

A novel synthetic protocol for the construction of eight-membered heterocycles by intramolecular palladium-catalyzed ortho C-H activation/C-C cyclization was proposed. With protosappanin A as the lead compound, 25 derivatives of 8-azaprotosappanin A were prepared in good yields by this protocol. Besides, a plausible reaction mechanism of the intramolecular cyclization was proposed. This strategy could be widely used in the synthesis of some natural products and drugs with large heterocycles due to the fast reaction rate and the mild conditions. In vitro antimicrobial activities of the synthesized compounds were assessed against the strains of Gram-positive bacteria and linezolid and ciprofloxacin were selected as the standard drugs. Some of the synthesized compounds were found to have excellent antibacterial activities.

Enhancing the synthetic utility of 3-haloaryne intermediates by their efficient Generation from readily synthesizable ortho-iodoaryl triflate-type precursors

Generation of 3-haloarynes from o-iodoaryl triflate-type precursors is reported. The method enables the generation of 3-fluorobenzyne with significantly high electrophilicity at -78 °C, allowing the formation of a three-component-coupled product between 3

Total synthesis of protosappanin A and its derivatives via palladium catalyzed ortho C-H activation/C-C cyclization under microwave irradiation

A total synthesis method for protosappanin A, which is a complex natural product with many biological activities, was developed with 6 linear steps. Dibenzo[b,d]oxepinones as the key intermediates of the synthetic route were prepared by a palladium-catalyzed ortho C-H activation/C-C cyclization under microwave irradiation. 25 derivatives of protosappanin A were obtained.

FIVE-COORDINATE BIS-PHENYLPHENOXY CATALYSTS FOR THE PREPARATION OF ETHYLENE-BASED POLYMERS

The invention provides a molecular transition metal complex selected from Formula 1, as described herein; an ethylene-based polymer; and a process to form the ethylene-based polymer, said process comprising polymerizing ethylene in the presence of at leas

CATALYST SYSTEMS FOR OLEFIN POLYMERIZATION

The instant invention provides procatalysts and catalyst systems for olefin polymerization, olefin based polymers polymerized therewith, and process for producing the same. In one embodiment, the instant invention provides a procatalyst comprising a metal