445-83-0

Basic information

• Product Name: 4-Fluoro-2-nitroanisole
• Synonyms: 4-FLUORO-1-METHOXY-2-NITROBENZENE;4-FLUORO-2-NITROANISOLE;4-Fluoro-2-nitro-methoxybenzene;4-Fluoro-2-nitroanisole 98%;4-Fluoro-2-nitroanisole98%;1-Methoxy-2-nitro-4-fluorobenzene;4-Fluoro-2-nitroanis
• CAS NO: 445-83-0
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171.13
• Product Categories: Other fluorin-contained compounds;blocks;FluoroCompounds;NitroCompounds;Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Nitro Compounds;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 445-83-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 62-64 °C(lit.)
• Boiling Point: 272.4 °C at 760 mmHg
• Flash Point: 118.5 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 0.0102mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Toluene
• CAS DataBase Reference: 4-Fluoro-2-nitroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-2-nitroanisole(445-83-0)
• EPA Substance Registry System: 4-Fluoro-2-nitroanisole(445-83-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 445-83-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder

General Description

4-Fluoro-2-nitroanisole is formed during the photolysis of the charge transfer complex of tetranitromethane and 4-fluoroanisole in dichloromethane at -20°C.

InChI:InChI=1/C7H6FNO3/c1-12-7-3-2-5(8)4-6(7)9(10)11/h2-4H,1H3

Upstream product

• 459-60-9 1-fluoro-4-methoxybenzene 
• 509-14-8 tetranitromethane 
• 371-41-5 4-Fluorophenol 
• 394-33-2 2-nitro-4-fluorophenol 
• 7697-37-2 nitric acid 
• 108-24-7 acetic anhydride 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 

Downstream Products

• 1258492-31-7 1-(3-(4-methoxy-3-nitrophenoxy)propyl)piperidine 
• 1145881-27-1 ethyl 2-(6-fluoro-3-methoxy-2-nitrobenzyl)acrylate 
• 439-88-3 5-fluoro-8-methoxyquinoline 
• 387-97-3 5-fluoro-8-quinolinol 
• 1512-84-1 N,O-bis-(1-cyano-1-methyl-ethyl)-N-(5-fluoro-2-methoxy-phenyl)-hydroxylamine 
• 451-91-2 (4-fluoro-2-iodo-phenoxy)-acetic acid 
• 3824-22-4 4-fluoro-2-iodo-1-methoxybenzene 
• 2267-25-6 2-chloro-4-fluoro-1-methoxy-benzene 
• 2713-29-3 2-iodo-4-fluorophenol 
• 452-08-4 2-bromo-4-fluoro-1-methoxybenzene 
• 1996-41-4 2-chloro-4-fluorophenol 
• 124782-77-0 7-(4-tert-Butyl-1-hydroxy-cyclohexyl)-4-methoxy-3H-benzooxazol-2-one 
• 124782-70-3 4-Methoxy-2-oxo-2,3-dihydro-benzooxazole-7-carboxylic acid phenylamide 
• 124782-73-6 7-(Hydroxy-phenyl-methyl)-4-methoxy-3H-benzooxazol-2-one 

Relevant articles and documents

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

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13C NMR Spectra of Substituted o-Nitroanisoles and n-Butyl o-Nitrophenyl Ethers

13C NMR analyses of substituted o-nitroanisoles and n-butyl o-nitrophenyl ethers are reported. Key Words: 13C NMR - o-Nitroanisoles - n-Butyl o-nitrophenyl ethers

REGIOSPECIFIC SYNTHESIS OF CERTAIN 1,2,3,4-TETRASUBSTITUTED BENZENES IN ONE STEP VIA A BENZENE CYCLIZATION

Tetrasubstituted benzenes of type 3 are obtained regiospecifically in a single step by the treatment of 1-fluoro-4-methoxy-5-carbo-tert-butoxy aniline with tert-butyllithium followed by reaction with an elecrophile.