27143-12-0

Basic information

• Product Name: ethyl chloro[(2,4-dichlorophenyl)hydrazono]acetate
• Synonyms: ethyl chloro[(2,4-dichlorophenyl)hydrazono]acetate;Acetic acid, chloro[(2,4-dichlorophenyl)hydrazono]-, ethyl ester
• CAS NO: 27143-12-0
• Molecular Formula: C₁₀H₉Cl₃N₂O₂
• Molecular Weight: 295.54966
• Mol File: 27143-12-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 358.7°C at 760 mmHg
• Flash Point: 170.7°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 2.5E-05mmHg at 25°C
• Refractive Index: 1.576
• PKA: 10.39±0.10(Predicted)
• CAS DataBase Reference: ethyl chloro[(2,4-dichlorophenyl)hydrazono]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl chloro[(2,4-dichlorophenyl)hydrazono]acetate(27143-12-0)
• EPA Substance Registry System: ethyl chloro[(2,4-dichlorophenyl)hydrazono]acetate(27143-12-0)

Safety Data

• Hazardous Substances Data: 27143-12-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9Cl3N2O2/c1-2-17-10(16)9(13)15-14-8-4-3-6(11)5-7(8)12/h3-5,14H,2H2,1H3

Upstream product

• 554-00-7 2,4-Dichloroaniline 
• 64-19-7 acetic acid 
• 129493-70-5 3-oxo-2-(2-(2,4-dichlorophenyl)hydrazono)butanoic acid ethyl ester 
• 623-73-4 diazoacetic acid ethyl ester 
• 27165-13-5 2,4-Dichloro-benzenediazonium 
• 7782-50-5 chlorine 
• 10475-63-5 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester 
• 7791-25-5 sulfuryl dichloride 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 13617-98-6 2,4-dichlorophenyldiazonium chloride 

Downstream Products

• 921590-78-5 ethyl 5-[4-(benzyloxy)phenyl]-4-cyano-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate 
• 135590-91-9 mefenpyr-diethyl 
• 133120-72-6 Ethyl 1-(2,4-dichlorophenyl)-5-ethoxy-5-isopropylpyrazoline-3-carboxylate 
• 133120-73-7 Ethyl 1-(2,4-dichlorophenyl)-5-methoxy-5-t-butylpyrazoline-3-carboxylate 
• 133120-71-5 Ethyl 1-(2,4-dichlorophenyl)-5-isopropyl-5-methoxypyrazoline-3-carboxylate 

Relevant articles and documents

4-Cyano-5-(2-thiophenyl)-pyrazoles are high affinity CB1 receptor ligands

Pyrazoles bearing a 5-thiophenyl and a 4-cyano group were synthesised and tested for their affinity to the cannabinoid CB1 receptor showing in many cases single digit nanomolar Ki values and moderate to good selectivity towards the CB2 receptor. Some of these pyrazole ligands, such as 8g, displayed relatively low lipophilicity (experimental logP 90) suggesting that these compounds may behave as peripherally restricted CB1 ligands. Furthermore, 2-fluoroethyl carboxamides 8d, 8h and 8l are interesting candidates for further development into PET tracers. This journal is

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists

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Preparation method of mefenpyr-diethyl

The invention relates to a preparation method of mefenpyr-diethyl, which specifically comprises the following steps: (a) mixing ethyl 2-chloroacetoacetate, 2,4-dichloroaniline, inorganic acid and water, and then adding a sodium nitrite aqueous solution to form a reaction system, and performing diazotization and substitution reactions, so as to obtain ethyl 2-chloro-2-(2,4-dichlorobenzene diazo) acetoacetate; and (b) adding an inorganic base into the reaction system to adjust the pH value to 5-7, then adding a bicarbonate aqueous solution to carry out a hydrolysis reaction to obtain ethyl 2-chloro-2-(2,4-dichlorobenzylidenehydrazino)acetate, then sequentially adding a polymerization inhibitor, ethyl methacrylate and the bicarbonate aqueous solution to carry out cyclization, and carrying outpost-treatment to obtain the mefenpyr-diethyl. Compared with the prior art, the intermediate generated through diazotization and substitution is stable, the intermediate does not need to be separated, the method is easy and convenient to operate, reaction conditions are mild, sodium bicarbonate (or potassium bicarbonate) is used for hydrolysis, the raw material price is low, and the dosage is small.