27148-07-8Relevant academic research and scientific papers
N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII
Ivanova, Jekaterīna,Carta, Fabrizio,Vullo, Daniela,Leitans, Janis,Kazaks, Andris,Tars, Kaspars,?alubovskis, Raivis,Supuran, Claudiu T.
, p. 3583 - 3589 (2017/05/29)
A series of N-substituted saccharins incorporating aryl, alkyl and alkynyl moieties, as well as some ring opened derivatives were prepared and investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). The widespread cytosolic is
Sulfonamide ligands attained through opening of saccharin derivatives
Robinson, Richard I.,Fryatt, Ross,Wilson, Claire,Woodward, Simon
, p. 4483 - 4489 (2007/10/03)
Literature N-alkylsaccharins (saccharin-R2) have been shown in some cases to be O-alkylated regioisomers by crystallography (3 structures). The genuine former species react with (S)-H2NCHR1CH 2OH at 101°C in dio
Retro-ene Reaction I: Reaction of N-Hydroxymethylsaccharin with Benzoyl Chlorides and Alkyl Halides
Kim, Sung-Kyu,Moon, Jung-Gyen,Lee, Sang-Gyeong,Choi, Sam-Young,Cho, Su-Dong,et al.
, p. 353 - 356 (2007/10/02)
N-Benzoylsaccharins, N-(saccharinylmethyl) benzoates and N-alkylsaccharins were synthesized from N-hydroxymethylsaccharin and the corresponding benzoyl chlorides or alkyl halides under different conditions.The reaction mechanisms are also discussed.
N-ALKYLATION OF SULFONAMIDES USING ANION EXCHANGE RESIN
Sanghavi, N.M.,Parab, V.L.,Patravale, B. S.,Patel, M. N.
, p. 1499 - 1504 (2007/10/02)
Mono-N-alkylated sulfonamides were synthesized in high yields by reacting the sulfonamides supported on anion exchange resin with alkyl halides.
