2-Propyl-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

Base Information

• Chemical Name: 2-Propyl-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide
• CAS No.: 27148-07-8
• Molecular Formula: C10H11NO3S
• Molecular Weight: 225.268
• Hs Code.: 2934100090
• Mol file: 27148-07-8.mol

Synonyms:1,2-Benzisothiazol-3(2H)-one,2-propyl-,1,1-dioxide;N-propyl-o-sulfobenzoic imide;2-propyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide;N-n-Propyl-saccharin;n-propyl saccharin;

Chemical Property of 2-Propyl-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

Chemical Property:

• PSA: 62.83000
• LogP: 2.25980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propyl-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

There total 7 articles about 2-Propyl-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(hydroxymethyl)saccharin (13947-20-1) + propyl bromide (106-94-5) → 2-propyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (27148-07-8)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Heating;

Reference yield: 71.0%

saccharin sodium salt (128-44-9) + propyl bromide (106-94-5) → 2-propyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (27148-07-8)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃;

DOI:10.1002/ejoc.200600508

Reference yield: 65.0%

propyl bromide (106-94-5) + saccharin (81-07-2) → 2-propyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (27148-07-8)

Guidance literature:

saccharin; With potassium carbonate; In water;

propyl bromide; In water; N,N-dimethyl-formamide; at 90 ℃; for 16h;

DOI:10.1016/j.bmc.2017.04.007

upstream raw materials:

2,2'-dithiodibenzoic acid dichloride

bis[2-(N-n-propylcarbamoyl)phenyl] disulfide

saccharin sodium salt

propyl bromide

Downstream raw materials:

N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-2-propylsulfamoylbenzamide

N-[(1S)-1-(chloromethyl)-2-methylpropyl]-2-[(propylamino)sulfonyl]benzamide

N-(n-propyl)benzamide

Refernces

• 1、 Ivanova, Jekaterīna,Carta, Fabrizio,Vullo, Daniela,Leitans, Janis,Kazaks, Andris,Tars, Kaspars,?alubovskis, Raivis,Supuran, Claudiu T.. "N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII". . p. 3583 - 3589. Retrieved 2017/05/29.
• 2、 Kim, Sung-Kyu,Moon, Jung-Gyen,Lee, Sang-Gyeong,Choi, Sam-Young,Cho, Su-Dong,et al.. "Retro-ene Reaction I: Reaction of N-Hydroxymethylsaccharin with Benzoyl Chlorides and Alkyl Halides". . p. 353 - 356. Retrieved 2007/10/02.