27149-27-5

Basic information

• Product Name: 2-(4-BROMO-PHENYL)-THIAZOLE
• Synonyms: 2-(4-BROMO-PHENYL)-THIAZOLE;Thiazole, 2-(4-bromophenyl)-
• CAS NO: 27149-27-5
• Molecular Formula: C₉H₆BrNS
• Molecular Weight: 240.12
• Mol File: 27149-27-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 52-53 °C
• Boiling Point: 324.3±44.0 °C(Predicted)
• Appearance: /
• Density: 1.563±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.92±0.10(Predicted)
• CAS DataBase Reference: 2-(4-BROMO-PHENYL)-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMO-PHENYL)-THIAZOLE(27149-27-5)
• EPA Substance Registry System: 2-(4-BROMO-PHENYL)-THIAZOLE(27149-27-5)

Safety Data

• Hazardous Substances Data: 27149-27-5(Hazardous Substances Data)

Usage

General Description

2-(4-Bromo-phenyl)-thiazole is a chemical compound with the molecular formula C9H6BrNS. It is a thiazole derivative with a 4-bromo-phenyl group attached to the thiazole ring. 2-(4-BROMO-PHENYL)-THIAZOLE is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active compounds. Its unique structure and properties make it a valuable intermediate in the production of drugs, pesticides, and other fine chemicals. Additionally, 2-(4-Bromo-phenyl)-thiazole has also been studied for its potential biological activities, such as antimicrobial and anticancer properties.

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 589-87-7 1,4-bromoiodobenzene 
• 121359-48-6 2-(tri-n-butylstannyl)thiazole 
• 623-00-7 4-bromobenzenecarbonitrile 
• 96159-83-0 2-(4-bromophenyl)-4,5-dihydro-1,3-thiazole 

Downstream Products

• 1073242-22-4 C₁₄H₁₄N₂O₂S 
• 1358778-98-9 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,3-thiazole 
• 1312474-12-6 (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[4-(1,3-thiazol-2-yl)phenyl]pyridin-1(2H)-yl}butanamide 
• 1358778-99-0 (2R)-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[4-(1,3-thiazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-(tetrahydro-2H-pyran-2-yloxy)butanamide 
• 176961-15-2 N-(3,4-Dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-thiazolyl)[1,1'-biphenyl]-2-sulfonamide 

Relevant articles and documents

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.