272129-02-9

Upstream product

• 170575-25-4 7-OTf-10DAB 
• 32981-86-5 10-deacetylbaccatin III 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 184586-78-5 (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-9-oxo-1,7,13-trihydroxytax-11-ene 
• 478161-64-7 (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-1,13-dihydroxy-9-oxo-7-trifluoromethanesulfonyloxytax-11-ene 

Downstream Products

• 173422-30-5 (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene 
• 333754-43-1 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-triisopropylsilyloxypropionate 
• 184586-81-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1,9,10,13-tetrahydroxytax-11-ene 
• 1353548-60-3 C₃₃H₄₅NO₉ 
• 184586-82-1 C₃₂H₄₀O₉ 

Relevant academic research and scientific papers

A new method for synthesis of 7-deoxytaxane analogues by hydrogenation of Δ6,7-taxane derivatives

A new method for the synthesis of 7-deoxytaxane analogues has been established through hydrogenation of Δ6,7-taxane derivatives. Among several catalysts examined, Pd-C was found to be a most effective catalyst for the preparation of target compound.

Taxane Compounds, Compositions And Methods

The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.