333754-43-1

Upstream product

• 333754-42-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-6,11-dien-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-triisopropylsilyloxypropionate 
• 1353548-62-5 C₂₉H₃₆O₉ 
• 1353548-63-6 C₃₃H₄₃NO₉ 
• 184586-82-1 C₃₂H₄₀O₉ 
• 173422-30-5 (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene 
• 272129-02-9 (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-6,11-diene 
• 170575-25-4 7-OTf-10DAB 
• 184586-81-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1,9,10,13-tetrahydroxytax-11-ene 
• 868847-44-3 S-(4-bromophenyl) (2R,3S)-3-[(tert-butoxycarbonyl)amino]-3-(3-fluoro-2-pyridinyl)-2-[(triisopropylsilyl)oxy]propanethioate 
• 1353548-60-3 C₃₃H₄₅NO₉ 
• 457962-01-5 (3R,4S)-cis-4-(3-fluoro-pyridin-2-yl)-3-triisopropylsilyloxy-2-azetidinone 
• 333754-33-9 (3R,4S)-cis-1-(t-butoxycarbonyl)-4-(3-fluoro-pyridin-2-yl)-3-triisopropylsilyloxy-2-azetidinone 
• 162475-68-5 10-deacetyl-9β-dihydrobaccatin III 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant academic research and scientific papers

Taxane Compounds, Compositions And Methods

The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.

PROCESS FOR PRODUCING PENTACYCLIC TAXANE

Taxan derivatives are produced efficiently and inexpensively, which are useful as oral-administrable antitumor compounds. A compound of formula (1) (wherein R 1 is an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a