27221-49-4

Basic information

• Product Name: 2,3-bis(chloroMethyl)pyridine hydrochloride
• Synonyms: 2,3-bis(chloroMethyl)pyridine hydrochloride;2,3-Bis-chloroMethyl-pyridine.HCl
• CAS NO: 27221-49-4
• Molecular Formula: C₇H₇Cl₂N*ClH
• Molecular Weight: 213
• Mol File: 27221-49-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-bis(chloroMethyl)pyridine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(chloroMethyl)pyridine hydrochloride(27221-49-4)
• EPA Substance Registry System: 2,3-bis(chloroMethyl)pyridine hydrochloride(27221-49-4)

Safety Data

• Hazardous Substances Data: 27221-49-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-bis(chloroMethyl)pyridine hydrochloride is used as a reactant in the preparation of an mGluR5 negative allosteric modulator. This application is significant because mGluR5 is a receptor that plays a crucial role in the central nervous system, and its modulation has been linked to the treatment of various neurological and psychiatric disorders, such as anxiety, depression, and schizophrenia.

Upstream product

• 38070-79-0 2,3-bis(hydroxymethyl)pyridine 
• 605-38-9 dimethyl 2,3-pyridinedicarboxylate 
• 423169-40-8 2,3-bis(hydroxymethyl)pyridine hydrochloride 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 

Downstream Products

• 1257241-37-4 6-(2,4-dimethoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 
• 45754-12-9 2,3-bis(chloromethyl)-pyridine 

Relevant articles and documents

Reaction safety: A critical parameter in the development of a scaleable synthesis of 2,3-bis-chloromethylpyridine hydrochloride

This report describes the development of a scaleable process to prepare 2,3-bis(chloromethyl)pyridine hydrochloride, 2, that is safe, economical, and environmentally acceptable. On a small scale this material is prepared using thionyl chloride as the solv

A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold

An approach to rel-(4aS,6R,7aR)-octahydro-1H-cyclopenta[b]pyridine-6-carboxylic acid—a bicyclic conformationally restricted γ-aminobutyric acid (GABA) analogue was developed. The eight-step sequence relied on the reaction of 2,3-bis(chloromethyl)pyridine and a C1-binucleophile and the catalytic reduction of the pyridine ring as the key steps and allowed for the preparation of the title compound in 9.0% overall yield. Assessment of the octahydro-1H-cyclopenta[b]pyridine scaffold geometry showed that this template can be considered truly three-dimensional.

DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS

Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

A novel synthesis of (4aS,7aS)-Octahydro-1H-pyrrolo[3,4-b]pyridine:An intermediate of Moxifloxacin Hydrochloride

A novel synthesis of (4aS, 7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine (1) is demonstrated alongwith recovery and reuse of chiral auxiliary naproxen. Further to this alternative stereoselective reduction procedures on 6-benzyl-5H- pyrrolo[3,4-b]pyridine-5,7(6H)-dione 3 enabling the desired chirality in the nonane 1 is demonstrated.

THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.

2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST

The present invention is directed to novel 2,3-dihydro-1H-isoindol-1-imine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the thrombin PAR-1 receptor antagonists.

A facile synthesis of 2,3-azaisoindoline

2,3-Azaisoindoline (4) was prepared via reaction of dichloride 11 with 2,4-dimethoxybenzyl amine followed by deprotection with trifluoroacetic acid and triethylsilane. Isolation of the unstable 2,3-azaisoindoline 4 was facilitated by conversion to the bis-HCl salt.

Quinolone derivatives and processes for preparing the same

The present invention relates to quinoline derivatives substituted in the 7-position by a trans-2,8-diazabicyclo?4.3.0!nonan-8-yl group having a broad antibacterial spectrum and to processes for preparing the same.