27224-31-3

Upstream product

• 120-72-9 indole 
• 22966-19-4 trans-4'-methoxychalcone 
• 959-23-9 4'-methoxychalcone 

Relevant academic research and scientific papers

Antimony trichloride-catalyzed Michael addition of indoles to the α,β-unsaturated ketones

Indoles undergo conjugate addition with α,β-unsaturated ketones in the presence of a catalytic amount of antimony trichloride under refluxing condition to afford the corresponding Michael adduct in excellent yields. The substitution on the indole ring occ

Enantioselective Michael-type Friedel-Crafts reactions of indoles to enones catalyzed by a chiral camphor-based Bronsted acid

Chiral Bronsted acid, D-camphorsulfonic acid, was found to be practical and efficient in the catalysis of the enantioselec-tive Michael-type Friedel-Crafts reactions of indoles with aromatic enones to afford the corresponding β-indolyl ketones in excellen

Metal-Free Dehydrogenative Double C-H Sulfuration to Access Thieno[2,3- b]indoles Using Elemental Sulfur

We report a base-promoted metal-free approach for the synthesis of thieno[2,3-b]indole derivatives. This method combined four C-H σ-bond cleavage reactions of two different kinds of C-H bonds and two C-S σ-bond formation processes. A series of thieno[2,3-

Br2 as a novel Lewis acid catalyst for Friedel-Crafts alkylation of indoles with α,β-unsaturated ketones

The inexpensive Br2 can serve as a novel Lewis acid catalyst for Friedel-Crafts alkylation of indoles with α,β-unsaturated ketones. Under the catalysis of only 3 mol % of Br2, this Michael addition proceeded smoothly with high effici

In situ generation of Iron(iii) dodecyl sulfate as Lewis acid-surfactant catalyst for synthesis of bis-indolyl, tris-indolyl, Di(bis-indolyl), Tri(bis-indolyl), tetra(bis-indolyl)methanes and 3-alkylated indole compounds in water

Iron(iii) dodecyl sulfate as Lewis acid-surfactant catalyst was prepared in situ and effectively used in the synthesis of bis(indolyl)methanes and Michael reactions of indoles with α,β-unsaturated carbonyl compounds in water. Also, this method was used for the synthesis of 1,1,3-tri-indolyl compounds, producing good to excellent yield at room temperature.

Al(OTf)3 catalysed Friedel-Crafts Michael type addition of indoles to α,β-unsaturated ketones with PEG-200 as recyclable solvent

An Al(OTf)3 catalysed efficient Friedel-Crafts Michael type addition of indoles to α,β-unsaturated ketones using recyclable PEG-200 as an alternative reaction solvent is disclosed. The reaction under microwave irradiation is clean, leads to exc

Catalytic conjugate addition of indole to α,β-unsaturated ketones by Co(ClO4)2·6H2O/bis-Schiff base complexes

Co(ClO4)2·6H2O/bis-Schiff base complexes promoted the conjugate addition of indole to α,β- unsaturated ketones under mild conditions, giving the corresponding addition products with high yields. And the complex has been ch

Al-MCM-41 as a mild and ecofriendly catalyst for Michael addition of indole to α,β-unsaturated ketones

Mesoporous Al-MCM-41 catalyzes the chemoselective Michael addition reaction between indoles and α,β-unsaturated ketones to afford β-indolylketones at room temperature with excellent yields. The higher catalytic activity is attributed to Lewis acidic Al and the large surface area. The catalyst is readily recovered and reused more than six times without loss in its catalytic activity. The substitution at the indole nucleus occurs exclusively at the 3-position and N-alkylation products are not observed.

Synthesis and application of modified silica sulfuric acid as a solid acid heterogeneous catalyst in Michael addition reactions

Figure represented. Modified silica sulfuric acid (MSSA) as a new type of silica sulfuric acid was prepared and effectively used in the conjugate addition of indole, pyrrole, and thiols with Michael acceptors under mild conditions at room temperature. Als

Conjugate addition of indoles to aα,β-Unsaturated Ketones Using a Broonsted acid ionic liquid as an efficient catalyst

The Broonsted acid ionic liquid [PyN(CH2)4SO 3H][p-CH3PhSO3] has been reported as an efficient catalyst for the Michael addition reaction of indoles to aα,β-unsaturated ketones. Satisfactory results were obtaine