27226-57-9Relevant academic research and scientific papers
Formylation reaction in series of meso-tetraaryl substituted porphyrins and chlorins
Mironov,Moskalchuk,Shashkov
, p. 261 - 267 (2004)
The formylation of nickel complexes of meso-tetraaryl substituted porphyrins and chlorins was studied. An obvious regioselectivity was observed for the introduction of the first and subsequent formyl groups into chlorins.
MnO2 instead of quinones as selective oxidant of tetrapyrrolic macrocycles
Nascimento, Bruno F.O.,Rocha Gonsalves, António M.d'A.,Pineiro, Marta
experimental part, p. 395 - 398 (2010/06/12)
Porphyrins and chlorins were generated through dehydrogenation of the corresponding porphyrinogen and bacteriochlorin precursors using activated manganese dioxide and focused microwave irradiation. The application of this inexpensive heterogeneous oxidant under microwave heating conditions, instead of the quinones usually employed in conventional methodologies, allowed short reaction times, simple overall work-ups and good yields.
Improved syntheses of 5,10,15,20-tetrakisaryl- and tetrakisalkylporphyrins
Johnstone, Robert A.W.,Nunes, M. Luisa P.G.,Pereira, Mariette M.,D'A Rocha Gonsalves, Antonio M.,Serra, Arménio C.
, p. 1423 - 1437 (2007/10/03)
Three significant modifications to existing methods for the preparation of the important 5,10,15,20-tetrakisarylporphyrins have improved isolated yields, simplified work-up and made large-scale synthesis feasible. Two tetrakisalkylporphyrins were also produced. A two-stage approach using hydrogen peroxide in acetic acid as second stage oxidant gave good yields but for ease of isolation and convenience in working on a large scale, the one-pot approach is preferred. No one method appears to be suitable for all such tetrakisarylporphyrins and, for best yields, the method of preparation needs to be chosen carefully. Application of statistical optimisation techniques (factorial two design and simplex operation) led to considerably enhanced yields for the one-pot method. For one of the two-stage modifications, significant amounts of chlorins were observed, sometimes of such magnitude as to make it suitable as a method for their preparation.
