27230-23-5

Upstream product

• 56680-30-9 1-methyl-1,3-dihydro-3-<2-phenyl-2-oxoethylidene>-2H-indole-2-one 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 98-86-2 acetophenone 
• 91-56-5 indole-2,3-dione 
• 60463-77-6 1-methyl-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 149846-20-8 (E)-5,7-dichloro-1-methyl-2-oxoindolin-3-ylidene acetophenone 
• 106009-19-2 1-methyl-5,7-dichloroisatin 

Downstream Products

• 844-49-5 1-methyl-3-(2-oxo-2-phenylethyl)indolin-2-one 
• 128316-88-1 3'-amino-2',5'-dihydro-1-methyl-6'-phenyl-2'-thioxospiro<3H-indole-3,4'(3'H)-pyrimidin>-2(1H)-one 
• 97100-26-0 2-Amino-4-(1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-phenyl-furan-3-carboxylic acid ethyl ester 
• 97100-17-9 2-[1-(1-Methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-2-oxo-2-phenyl-ethyl]-malononitrile 
• 97100-22-6 2-Amino-4-[1-methyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-5-phenyl-4,5-dihydro-furan-3-carbonitrile 
• 40526-76-9 1-methyl-5'-phenyl-2',4'-dihydrospiro[dihydroindole-3,3'-pyrazol]-2-one 
• 1400564-53-5 C₂₃H₁₅NO₂ 
• 1417157-94-8 1-methyl-2'-phenyl-1,3,1',5',6',7'-hexahydro-3,3'-biindolyl-2,4'-dione 

Relevant academic research and scientific papers

Interrupted Morita-Baylis-Hillman-Type Reaction of α-Substituted Activated Olefins

It was demonstrated that 3-olefinic oxindoles could generate zwitterionic enolate species with tertiary phosphines and undergo C-C bond formation with various electrophiles in an interrupted Morita-Baylis-Hillman-type reaction manner, followed by a dephos

Synthesis of CF3-containing 3,3′-cyclopropyl spirooxindoles by sequential [3 + 2] cycloaddition/ring contraction of ylideneoxindoles with 2,2,2-trifluorodiazoethane

A [3 + 2] cycloaddition/ring contraction sequence of ylideneoxindoles with in situ-generated 2,2,2-trifluorodiazoethane without the use of any transition-metal catalyst has been developed. The reaction provides efficient access to biologically important a

Diastereoselective trans Cyclopropanation of 3-Alkylidene Oxindoles with in Situ Generated α-Diazo Carbonyls or α,β-Unsaturated Diazo Compounds

An efficient diastereoselective trans cyclopropanation of 3-alkylidene oxindoles with in situ generated α-diazo carbonyl compounds or α,β-unsaturated diazo compounds under metal-free conditions has been developed to synthesize 3-spirocyclopropyl-2-oxindol

DBU-catalyzed [3 + 2] cycloaddition and Michael addition reactions of 3-benzylidene succinimides with 3-ylidene oxindoles and chalcones

A metal-free DBU catalyzed protocol has been developed for the regioselective [3 + 2] cycloaddition reactions of 3-benzylidene succinimides with 3-ylidene oxindoles to furnish spirooxindole derivatives. The 3-benzylidene succinimides underwent Michael addition with chalcones to provide benzylidene succinimide-tethered propanones. All the reactions proceeded under mild conditions and the products were isolated by simple filtration and washing with ethanol in good yields. The current methodology utilizes simple precursors and provides functionally-rich succinimides with two to five contiguous stereocenters in excellent diastereoselectivity and with complete regioselectivity.

Spiro indolone compound as well as, preparation, method and pharmaceutical composition and application thereof

Spiro indolone compounds, a preparing method, a medicine composition and uses of the compounds are disclosed. In particular, the invention provide spiro indolone compounds shown as a formula I or II, a preparing method of the spiro indolone compounds and

Base-catalyzed controllable reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates for the synthesis of amidoacrylates and spiroaziridine oxindoles

A base-catalyzed divergent reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates has been developed to provide efficient access to various amidoacrylates and spiroaziridine oxindoles with generally high yields, which should be potentially useful in drug discovery.

Chemistry of phosphorus ylides. Part 37. The reaction of phosphonium ylides with indoles and naphthofurans. Synthesis of phosphanylidenes, pyrans, cyclobutenes, and pyridazine as antitumor agents

The reaction of the stabilized phosphonium ylides 2a, b with indolinones 1a, b and naphthofuranone 13 afforded the corresponding propylidene and ethylidene derivatives 4a-d and 14a, b. On the other hand, the active phosphacumulenes 5a, b react with compounds 4a-d by [4 + 2]-cycloaddition to give the stable phosphanylidene indole pyranones 6a-h. Although compounds 14a, b afforded the naphthofuropyrans 16a-d and triphenylphosphane. Moreover, the phosphallene ylide 7 react with compounds 4a-d and 14a, b to give phosphanylidenecyclobuteneindoline 9a-d and naphthalenones 18a, b, respectively. In addition, the naphthofuropyridazine 21 was obtained from the reaction of the hydrazone 19 and the phosphacumulene 5a. The antitumor activity of some of the new compounds was evaluated, in vitro, against colon and hepatocellular carcinoma cell lines. They showed values closed to that recorded by the reference drug Doxorubicin.

Isocyanide-based multicomponent reactions: Concise synthesis of spirocyclic oxindoles with molecular complexity by using a [1,5]-hydrogen shift as the key step

A concise multicomponent reaction of isocyanide, α-substituted allenoate, and methyleneindolinone has been disclosed. This protocol provides a fast and straightforward approach to synthesize unusual tricyclic oxindoles in an efficient and atom-economic manner. Mechanistically, the present cycloaddition may proceed through a cascade sequence involving double Michael addition, double cyclization, double [1,5]-hydrogen shift, and group migration. The introduction of a special alkyl group to the allenoate is believed to play a key role in the cascade reaction. This method also features a broad substrate scope, which is particularly useful for the delivery of a large number of compounds. Shift your perspective! An unprecedented cascade reaction, under mild conditions, involving a double Michael addition, double cyclization, and double [1,5]-hydrogen shift, followed by group migration is disclosed. This reaction offers a fast and straightforward approach to unusual polycyclic spirooxindoles (see scheme).

3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: Potential candidates for chemoprevention

Induction of cytoprotective phase 2 enzymes through inhibition of Keap1, a repressor of transcription factor Nrf2, is a cancer-prevention strategy. Compounds that elicit antiinflammatory and cytoprotective effects are promising candidates for chemoprevent

Synthesis and structure of new oxoindoles

The synthesis and study of the structure of new oxoindoles has been carried out. The molecular and crystal structure, and the stereochemistry atom of C(3) of 1,2-diacetyl-5′-phenyl(2′,4′ dihydrospiro[3H-indol-3, 3′-[3H]pyrazol]-2-(1H)-one have been establ