27240-64-8

Upstream product

• 6451-86-1 5-benzyloxy-2-bromo-4-methoxybenzaldehyde 
• 24958-42-7 2-bromo-4-methoxy-5-benzyloxy-benzoic acid 

Downstream Products

• 24958-43-8 5-benzyloxy-N-[2-(4-benzyloxy-phenyl)-ethyl]-2-bromo-4-methoxy-N-methylbenzamide 
• 206002-18-8 N-[(diphenylphosphinyl)methyl]-N-[(4-methoxyphenyl)methyl]-5-(benzyloxy)-2-bromo-4-methoxybenzamide 

Relevant academic research and scientific papers

Syntheses and Preparations of Narwedine and Related Novel Compounds

The present invention relates to a process for preparing racemic narwedine (which can be can be kinetically resolved) to yield (?)-narwedine and which is the biogenic precursor of (?)-galanthamine) and the use thereof as a starting material for producing (?)-galanthamine. The invention further includes processes for preparing (?)-galanthamine and (?)-galanthamine hydrobromide, as well as related novel compounds.

PROCESS FOR PREPARATION OF BENZAZEPINE

This invention discloses a process for manufacture of galanthamine, which involves a stereoselective reduction step to get the desired isomer of galanthamine. The current embodiment also discusses the method for improving the chiral and chemical purity of galanthamine and galanthamine salts.

Processes for the preparation of derivatives of 4a, 5, 9, 10, 11, 12-hexahydro-6H-benzofuro-[3a, 3, 2-ef][2]benzazepine

The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a, 5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine.

A versatile synthesis of poly- and diversely substituted isoindolin-1- ones

A variety of diversely substituted isoindolin-1-ones have been prepared by alkaline cleavage of the C-P bond in the corresponding phosphorylated lactams obtained by base-induced aryne-mediated cyclization of o-halogeno-N- (phosphinylmethyl)benzamide derivatives.