24958-43-8Relevant academic research and scientific papers
Alternative total synthesis of (-)-galanthamine hydrobromide
Reddy, Jambula Mukunda,Kumar, Kotagiri Vijay,Raju, Veeramalla,Bhaskar, Bolguddu Vijay,Himabindu, Vurumidi,Bhattacharya, Apurba,Sundaram, Venkatram,Banerjee, Rahul,Reddy, Ghanta Mahesh,Bandichhor, Rakeshwar
, p. 2138 - 2149 (2008/09/21)
An alternative total synthesis of (-)-galanthamine (1) hydrobromide, employing ecofriendly amidation, oxidative coupling, and classical resolution strategies is accomplished. Copyright Taylor & Francis Group, LLC.
Syntheses and Preparations of Narwedine and Related Novel Compounds
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Page/Page column 3; 9, (2009/01/20)
The present invention relates to a process for preparing racemic narwedine (which can be can be kinetically resolved) to yield (?)-narwedine and which is the biogenic precursor of (?)-galanthamine) and the use thereof as a starting material for producing (?)-galanthamine. The invention further includes processes for preparing (?)-galanthamine and (?)-galanthamine hydrobromide, as well as related novel compounds.
PROCESS FOR PREPARATION OF BENZAZEPINE
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Page/Page column 21-22, (2008/06/13)
This invention discloses a process for manufacture of galanthamine, which involves a stereoselective reduction step to get the desired isomer of galanthamine. The current embodiment also discusses the method for improving the chiral and chemical purity of galanthamine and galanthamine salts.
Preparation of (-)-galantamine hydrobromide
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Page/Page column 7, (2008/06/13)
A process for preparing (?)-galantamine hydrobromide.
Processes for the preparation of derivatives of 4a, 5, 9, 10, 11, 12-hexahydro-6H-benzofuro-[3a, 3, 2-ef][2]benzazepine
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Example 32, (2008/06/13)
The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a, 5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine.
SYNTHESIS OF GALANTHAMINE AND RELATED ALKALOIDS - NEW APPROARCHES. I.
Vlahov, Radoslav,Krikorian, Dikran,Spassov, Grigor,Chinova, Maja,Vlahov, Ioncho,et al.
, p. 3329 - 3346 (2007/10/02)
Modifications of protecting groups and of the oxidative coupling conditions led to pure crystalline intermediates in the synthesis of galanthamine derivatives and gave dienone A in better yields than reported before.The E-configuration of amide 3' in crystalline state has been determined by X-ray diffraction.Streptomyces affinis 6737 reduces A to the optically active (-)-epigalanthamine derivative C, whose absolute configuration was determined by Bijvoet's method.Nematospora corylii CBS 2608 reduces to racemic B.With Ashbya gossypii IFO 1355 a mixture of racemic B and of optically active C is obtained.Some other microbial transformations are described.
