27259-73-0Relevant articles and documents
A new fluorescent probe for ultrasensitive detection of phosgene in solution and the gas phase
Zeng, Fenfen,Bao, Guangbo,Zhou, Baocheng,Han, Yifeng
, p. 5631 - 5636 (2021)
Due to the high toxicity and commercial availability of phosgene, it is urgent to detect phosgene quickly and reliably to deal with its potential serious threat to public safety. A new 2-(2-aminophenyl)quinazolin-4(3H)-one (APQ) based fluorescent probeAPQhas been developed as a rapid, highly sensitive, and selective sensor for phosgene in this work.APQdisplays very weak fluorescence in acetonitrile due to the free rotation of the 2-aminophenyl moiety. After reacting with phosgene,APQis converted to a new restricted intramolecular motion productAPQU1. Owing to the specific cyclization reactions,APQexhibits an obvious fluorescence response toward phosgene with a large Stokes shift (104 nm), instant response (less than 20 s), and low detection limit (0.16 ppm). Moreover, theAPQ-loaded test strip was prepared and demonstrated to have practical utility in detecting phosgene vapor.
Palladium(II) N^O Chelating Complexes Catalyzed One-Pot Approach for Synthesis of Quinazolin-4(3 H)-ones via Acceptorless Dehydrogenative Coupling of Benzyl Alcohols and 2-Aminobenzamide
Balaji, Sundarraman,Balamurugan, Gunasekaran,Ramesh, Rengan,Semeril, David
, p. 725 - 734 (2021/04/06)
A convenient protocol for the one-pot synthesis of quinazolin-4(3H)-ones using palladium(II) complexes via dehydrogenative coupling of readily available benzyl alcohols and 2-aminobenzamide has been described. New structurally related Pd(II) N^O chelating complexes of general configuration [Pd(L)Cl(PPh3)] (where L = dimethylamino benzoylhydrazone ligands) have been designed and synthesized. The formation of the complexes has been recognized by analytical and spectral methods (FT-IR, NMR, HR-MS). The presence of a square-planar geometry around the palladium(II) ion was confirmed by single crystal X-ray diffraction study. A wide range of substituted quinazolinones have been successfully achieved from a diverse range of benzyl alcohols in good to excellent yields using 1.0 mol % of catalyst loading under aerobic conditions. Furthermore, control experiments reveal that the dehydrogenative coupling reaction involves initially the formation of an aldehyde intermediate and subsequent formation of a cyclic aminal intermediate.
Method for photocatalytic synthesis of quinazolinone compound in aqueous phase (by machine translation)
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Paragraph 0030; 0031; 0032; 0033; 0040; 0041, (2020/11/22)
The method comprises the following steps: taking the compound of the formula (I) and the compound of the formula (II) as a solvent, adding a photocatalyst and a phase transfer catalyst to obtain the quinazolinone compound (III) under the condition of alkali and visible light. Compared with the prior art, the method not only can be applied to a large amount of functional groups, has high yield, few byproducts, and is simple and safe to operate, low in cost and environment-friendly. Wherein R is hydrogen or R1 Is H, C1 - C4 alkoxy, halogen or nitro; R2 Is H, substituted or unsubstituted phenyl, 2 - pyridyl or 2 - thienyl; the substituted phenyl is phenyl substituted by amino, nitro, C1 - C4 alkyl or C1 - C4 alkoxy. (by machine translation)
