27260-84-0

Upstream product

• 87740-10-1 phenylmethylthio-1-nitrobenzene 
• 100-39-0 benzyl bromide 
• 626-01-7 3-Iodoaniline 
• 591-19-5 m-Bromoaniline 
• 100-44-7 benzyl chloride 
• 22948-02-3 3-aminothiophenol 
• 3814-18-4 3-nitrothiophenol 

Downstream Products

• 87739-43-3 1-(3-Benzylsulfanyl-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diamine; hydrochloride 
• 228728-78-7 ethyl 7-(benzylsulfanyl)-4-hydroxy-3-quinolinecarboxylate 
• 917894-15-6 3-(benzylthio)-phenylcyanamide 
• 917894-18-9 N-(2-chloro-5-methylthiophenyl)-N'-(3-thiophenyl)-N'-methyl-guanidine 
• 917894-16-7 N-(3-benzylthiophenyl)-N-methylcyanamide 

Relevant academic research and scientific papers

IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES

The invention provides a compound of formula (I); or a salt or solvate thereof, wherein: R1 is hydrogen or C1-4alkyl; R2 and R4 are each independently selected from C1-4 alkyl, [11C] C1 4alkyl, and [18F]-C1-4 fluoroalkyl provided that at least one of R2 and R4 is [11C] C1 4alkyl or [18F]-C1-4 fluoroalkyl; and R3 is halo. Such compounds having use for imaging central nervous system receptors.

A facile one-pot preparation of alkyl aminoaryl sulfides for the synthesis of GW7647 as an agonist of peroxisome proliferator-activated receptor α

We have developed two simple and high yielding one-pot syntheses of alkyl aminoaryl sulfides containing a series of four-steps: in situ protection of the free amine by reaction with a Grignard reagent, halogen-lithium exchange, sulfur insertion, and a substitution reaction with various electrophiles. Through this protocol, we have successfully synthesized tert-butyl-2-[4-(2-aminoethyl) phenylsulfanyl]-2-methylpropanoate, a key intermediate for the synthesis of GW7647 and GW9578 (ureido-TiBAs), in 92% yield. Furthermore, we were able to improve the overall yield of, GW7647 to 66%, 3 times the yield previously reported.

4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines

The inhibition of dihydrofolate reductase fron chicken liver and from Lactobacillus casei has been studied with 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines. It was found that for the chicken enzyme, inhibitor potency for 101 triazines was correlated by a given equation. The mathematical models obtained from correlation analysis are compared with stereo color graphics models.

Thio-substituted 2-oxo-indolines

Thio-substituted 2-oxoindolines have the formula SPC1 In which one of R or R1 is hydrogen and the other is R2 --S--, in which R2 is C1 -C3 alkyl, benzyl, halobenzyl, nitrobenzyl, C1 -C