2727-69-7Relevant articles and documents
I-Aza[2.2]metacyclophane: A ring strained secondary amine
Muller,Vogtle
, p. 759 - 760 (1995)
1-Aza[2.2]metacyclophane (1), the hitherto most strained cyclophane with a free NH group in the bridge, is synthesised for the first time with a remarkable yield in the last step by a combination of an intramolecular C-C-coupling reaction and removal of t
Carbon-Carbon Bond Formation of Trifluoroacetyl Amides with Grignard Reagents via C(O)-CF3 Bond Cleavage
Zhu, Longzhi,Le, Liyuan,Yan, Mingpan,Au, Chak-Tong,Qiu, Renhua,Kambe, Nobuaki
, p. 5635 - 5644 (2019/05/10)
The reaction of trifluoroacetyl amides with Grignard reagent for the substitution of CF3 group with various alkyl or aryl groups is described. A variety of aryl, quinolin-8-yl, and (hetero)alkyl functional groups as well as F, Cl, and Br atoms are well tolerated. These moisture-stable and easily available trifluoroacetyl amides can be conveniently obtained and used as new versatile precursors for isocyanates. The control experiments show that the reaction proceeds via an isocyanate intermediate and/or alkoxide/amide dual anionic intermediate.
Trifluoroacetylation of arylamines using poly-phosphoric acid trimethylsilylester (PPSE)
López, Simón E.,Pérez, Yelsi,Restrepo, Jelem,Salazar, José,Charris, Jaime
, p. 566 - 569 (2007/12/27)
A new, simple and useful procedure is described for the trifluoroacetylation of arylamines using trifluoroacetic acid and poly-phosphoric acid trimethylsilylester (PPSE) as the condensation agent.