27277-03-8

Basic information

• Product Name: (5-Amino-1H-[1,2,4]triazol-3-yl)-methanol
• Synonyms: (3-aMino-1H-1,2,4-triazol-5-yl)Methanol;3-aMino-5-hydroxyMethyl-1,2,4-triazole;3-aMino-5-hydroxyMethyl-s-triazole;(3-amino-3H-1,2,4-triazol-5-yl)methanol
• CAS NO: 27277-03-8
• Molecular Formula: C3H6N4O
• Molecular Weight: 114.10594
• Mol File: 27277-03-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 461.3 °C at 760 mmHg
• Flash Point: 232.8 °C
• Appearance: /
• Density: 1.623 g/cm³
• Vapor Pressure: 2.62E-09mmHg at 25°C
• Refractive Index: 1.712
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.14±0.40(Predicted)
• CAS DataBase Reference: (5-Amino-1H-[1,2,4]triazol-3-yl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5-Amino-1H-[1,2,4]triazol-3-yl)-methanol(27277-03-8)
• EPA Substance Registry System: (5-Amino-1H-[1,2,4]triazol-3-yl)-methanol(27277-03-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 27277-03-8(Hazardous Substances Data)

Usage

General Description

(5-Amino-1H-[1,2,4]triazol-3-yl)-methanol is a chemical compound with the molecular formula C2H5N3O. It is a derivative of 1,2,4-triazole and is a white crystalline solid at room temperature. (5-Amino-1H-[1,2,4]triazol-3-yl)-methanol is used in organic synthesis as a starting material for the preparation of various pharmaceuticals, agrochemicals, and other organic compounds. It has also been studied for its potential biological activities, including antifungal and antibacterial properties. Additionally, (5-Amino-1H-[1,2,4]triazol-3-yl)-methanol has been investigated for its potential use in the development of new materials, such as polymers and coordination complexes. Due to its versatile properties, this compound is of interest to researchers in a variety of fields, including chemistry, biology, and materials science.

InChI:InChI=1/C3H6N4O/c4-3-5-2(1-8)6-7-3/h8H,1H2,(H3,4,5,6,7)

Upstream product

• 79-14-1 glycolic Acid 
• 2582-30-1 aminoguanidine bicarbonate 
• 79-17-4 aminoguanidine 

Downstream Products

• 749929-28-0 (6-chloro-[1,2,4]triazolo[1,5-a]pyrimidine-2-yl)methanol 
• 54535-00-1 (5,7-dimethyl- [1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol 

Relevant articles and documents

Exploration of low-melting energetic compounds: Influence of substituents on melting points

To investigate the effect of substituents on nitrate-based energetic compounds, a class of energetic compounds based on triazole nitrates were designed, synthesized, and characterized. Crystal structures of some compounds were proved by single crystal X-ray diffraction. The analysis of the melting point of each compound shows that the effect of the substituent on the melting point of the compound follows a trend of -N3 > -NO2 > -ONO2 > -NNO2. To verify the trend, we used Hirshfeld surfaces to analyze the intermolecular effects of the substituents. The compounds (3-nitro-1H-1,2,4-triazol-5-yl)methyl nitrate and (5-azido-1H-1,2,4-triazol-3-yl)methyl nitrate, were found to be potential melt cast explosive carriers or energetic plasticizers. This journal is

Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same

The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

TRIAZOLOPYRIMIDINE DERIVATIVES WHICH ARE ANGIOTENSIN II RECEPTOR ANTAGONISTS, THEIR METHODS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT

The present invention relates to the derivatives of the formula STR1 and their tautomeric forms, as well as their addition salts, and to their use in therapeutics, especially for the treatment and prevention of cardiovascular diseases and in particular for the treatment of hypertension, cardiac insufficiency and diseases of the arterial wall, especially atherosclerosis.