272787-72-1Relevant academic research and scientific papers
Synthetic studies on the HIJK-ring fragment of ciguatoxin
Liu, Tong-Zhu,Isobe, Minoru
, p. 5391 - 5404 (2007/10/03)
Synthesis of the tetracyclic HIJK-ring fragment of ciguatoxin with high stereoselectivity has been achieved starting from a sugar derivative directed toward the synthesis of the right part of ciguatoxin. Sonogashira coupling of a vinyl iodide with an acetylene derivative, cobalt complex-mediated (seven- and eight-membered ring) cyclizations and a heteroconjugate addition reaction play important roles in the current research work. (C) 2000 Elsevier Science Ltd.
Synthesis of the H-I-J tricyclic fragment of ciguatoxin, a marine polyether toxin
Liu, Tong-Zhu,Isobe, Minoru
, p. 266 - 268 (2007/10/03)
During the course of our synthetic studies on ciguatoxin, synthesis of H-I-J tricyclic fragment has been stereoselectively achieved starting from a D-glucal derivative. The key steps are Sonogashira coupling reaction and cobalt complex-mediated oxocane cyclization.
