27301-45-7

Usage

Chemical Class

Pyrazole derivatives
A 4-chlorophenyl group at the 5-position
A 4-methoxyphenyl group at the 3-position
A phenyl group at the 1-position

Biological Activities

Anti-inflammatory: Potential to reduce inflammation in biological systems.
Analgesic: Potential to alleviate pain sensations.

Potential Applications

Lead Compound: Could be used as a starting point for developing new drugs.
Disease Treatment: Potential for treating various diseases.

Utility in Research and Development

Chemical Research: Useful in studying chemical reactions and properties.
Pharmaceutical Development: Valuable in the creation of new pharmaceutical products.

Upstream product

• 6552-68-7 4'-methoxy-4-chlorochalcone 
• 100-63-0 phenylhydrazine 
• 1380819-96-4 C₂₂H₁₉ClN₂O 
• 1340547-59-2 C₁₈H₁₇ClO₂S 
• 75745-49-2 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole 

Relevant academic research and scientific papers

Regioselective synthesis of 1,3,5-trisubstituted pyrazoles

A new and a simple approach toward synthesis of 1,3,5-trisubstituted pyrazoles from chalcone arylhydrazones via oxidative cyclization has been achieved. 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone was successfully used as an oxidizing agent to give excellen

Regioselective synthesis of multisubstituted pyrazoles via cyclocondensation of β-thioalkyl-α,β-unsaturated ketones with hydrazines

Multisubstituted pyrazoles were efficiently synthesized by cyclocondensation of β-thioalkyl-α,β-unsaturated ketones with hydrazines under relatively mild conditions. A one-pot synthetic protocol through tandem Liebeskind-Srogl cross-coupling/cyclocondensation using a-oxo ketene dithioacetals as the starting materials was also realized for the same purpose.

4-(p-Chloro)phenyl-1,2,4-triazole-3,5-dione as a novel and reusable reagent for the oxidation of 1,3,5-trisubstituted pyrazolines under mild conditions

4-(p-Chloro)phenyl-1,3,4-triazole-3,5-dione is used as an effective oxidizing agent for the oxidation of 1,3,5-trisubstituted pyrazolines to their corresponding pyrazoles under mild conditions with moderate to good yields at room temperature.

Microwave-assisted aromatization of 1,3,5-trisubstituted 2-pyrazolines by Bi(NO3)3 · 5H2O, as a novel and convenient oxidizing agent

Bismuth(III) nitrate pentahydrate, Bi(NO3)3 · 5H2O, has been used as a mild, efficient, and inexpensive oxidant for the oxidative aromatization of several 1,3,5-trisubstituted 2-pyrazolines to pyrazoles in acetic acid unde

Tricholoroisocyanuric acid as a useful reagent in microwave-assisted aromatization of 1,3,5-trisubstituted 2-pyrazolines

An efficient aromatization of 1,3,5-trisubstituted 2-pyrazolines to their corresponding pyrazoles has been performed by tricholoroisocyanuric acid [TCCA] under microwave irradiation in excellent yields. It has been observed that the reactions occur more r

Microwave-assisted aromatization of 1,3,5-trisubstituted 2-pyrazolines by silica-supported N-bromosuccinimide as a useful reagent under solvent free 'dry' condition

An efficient aromatization of 1,3,5-trisubstituted 2-pyrazolines to theircorresponding pyrazoles by NBS was carried out under microwave irradiation and solvent-free conditions in moderate yields. It has also been observed that, by activating the NBS reage

N,N′,N,N′-tetrabromo-benzene-1,3-disulfonylamide as a novel reagent for oxidative aromatization of 1,3,5-trisubstituted pyrazolines under heterogeneous and solvent-free conditions

1,3,5-Trisubstituted pyrazolines were converted to the corresponding pyrazoles in good yields under heterogeneous and solvent-free conditions by N,N′,N,N′-tetrabromo-benzene-1,3-disulfonylamide [TBBDA] at ambient temperature.

Silica-supported 1,3-dibromo-5,5-dimethylhydantoin (DBH) as a useful reagent for microwave-assisted aromatization of 1,3,5-trisubstituted pyrazolines under solvent-free conditions

1,3,5-Trisubstituted pyrazolines are rapidly and conveniently oxidized to their corresponding pyrazoles by 1,3-dibromo-5,5-dimethylhydantoin (DBH) under microwave irradiation and solvent-free conditions. The presence of silica gel as a supporting agent is

Trichloroisocyanuric acid as a novel oxidizing agent for the oxidation of 1,3,5-trisubstituted pyrazolines under both heterogeneous and solvent free conditions

Trichloroisocyanuric acid is used as an effective oxidizing agent for the oxidation of 1,3,5-trisubstituted pyrazolines to their corresponding pyrazoles under both heterogeneous and also solvent free conditions with good yields at room temperature.