75745-49-2

Upstream product

• 6552-68-7 4'-methoxy-4-chlorochalcone 
• 100-63-0 phenylhydrazine 
• 1073-67-2 4-vinylbenzyl chloride 
• 20433-10-7 5-(4-methoxyphenyl)-2-phenyl-2H-tetrazole 
• 6552-63-2 4'-chloro-4-methoxy-chalcone 
• 99-91-2 para-chloroacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 88700-24-7 1-<(methylthio)thiocarbonylmethyl>pyridinium iodide 
• 6552-68-7 4-chloro-4'-methoxy-chalcone 

Downstream Products

• 27301-45-7 3-p-anisyl-5-p-chlorophenyl-1-phenylpyrazole 
• 1207173-27-0 1-(4'-thiocyanophenyl)-3-(4'-methoxyphenyl)-5-(4'-chlorophenyl)-pyrazoline 

Relevant academic research and scientific papers

An eco-friendly synthesis of 2-pyrazoline derivatives catalysed by CeCl 3· 7 H 2O

Abstract: 1,3,5-triaryl-2-pyrazoline derivatives were synthesised by a condensation reaction between chalcones and phenyl hydrazine using cerium chloride heptahydrate as a catalyst. All these reactions were carried out in ethyl lactate (70%) as a green solvent. Easy and efficient work up, recyclability of solvent and catalyst are the key merits of this protocol. Graphical Abstract:: SYNOPSIS A facile protocol for the synthesis of 1,3,5-triaryl-2-pyrazolines is described. The solvent ethyl lactate, obtained from renewable sources, is biodegradable. The catalyst CeCl 3· 7 H 2O is a water-tolerant Lewis acid with low toxicity. Easy and clean work up, recyclable solvent and catalyst are merits of the protocol. The reaction works well for all systems giving good yields of the desired products.[Figure not available: see fulltext.].

Catalytic Synthesis of Chalcones and Pyrazolines Using Nanorod Vanadatesulfuric Acid: An Efficient and Reusable Catalyst

Nanorod vanadatesulfuric acid (VSA NRs), as a recyclable and ecologically benign catalyst, was used for the one-pot synthesis of chalcones and 1,3,5-triaryl-2-pyrazolines (TAPs). Chalcones were prepared via the condensation of substituted acetophenones with aryl-aldehydes under solvent-free conditions. Subsequently, the synthesized chalcones were used for the catalytic synthesis of TAPs via two-component condensation with phenyl hydrazine in refluxing ethanol. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate of high purity. Compared to conventional procedures, the present protocol offers several advantages such as simplicity of the procedure, appropriate reaction times, high to excellent yields, easily work-up, recoverability, and reusability of the catalyst, and simple purification of the products.

Thiocyanation on n-benzene rings of 1,3,5-trisubstituted pyrazolines with oxone

An efficient aromatic thiocyanation of 1,3,5-trisubstituted pyrazolines occurred regioselectively at the para position of N-benzene rings using ammonium thiocyanate as a thiocyanation reagent and oxone as an oxidant.

Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition

A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 n

Silica-supported synthesis of some 1,3,5-trisubstituted 2-pyrazolines under solvent-free and microwave irradiation conditions

A simple method for the synthesis of 2-pyrazolines is described which occurs on silica surface under solvent-free conditions within 110-180 sec using microwave irradiation. The results obtained indicate that the use of silica gel as a support in pyrazolin

Synthesis of pyrazoline and isoxazoline in triethanolamine medium

Reactions of chalcones 1a-u with phenylhydrazine and hydrazine hydrate give pyrazolines 2a-u and with hydroxylamine hydrochloride yield isoxazolines 3a-c in triethanolamine medium. The structures of products are established by melting points, chemical studies and spectral data (IR and 1HNMR).

Reinvestigation of Thesing's Synthesis of 2-Pyridones using 1-(Methylthio-thiocarbonylmethyl)pyridinium Iodide

Starting from 1-(methylthiocarbonylmethyl)pyridinium iodide 1, several attemps were made to prepare 4,6-diaryl-2-pyridothiones.Synthesis of thioamides 2-10 was produced easily and with high yield, but thioamide behaves as a bad stabylising group.A modifie

Synthesis of Some New Pyrazolines from 4-Nitro- and 4-Chloro-4''-methoxybenzalacetophenones

Some new pyrazolines (III,IV) have been prepared by the reaction of chalkones with hydrazines.The new pyrazolines have been converted into different derivatives.The hitherto unknown reaction of pyrazolines with phthalic anhydride has also been described.