27338-44-9

Basic information

• Product Name: 1-Cyclohexene-1-propanoic acid
• CAS NO: 27338-44-9
• Molecular Formula: C9H14O2
• Molecular Weight: 154.209
• Mol File: 27338-44-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-Cyclohexene-1-propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclohexene-1-propanoic acid(27338-44-9)
• EPA Substance Registry System: 1-Cyclohexene-1-propanoic acid(27338-44-9)

Safety Data

• Hazardous Substances Data: 27338-44-9(Hazardous Substances Data)

Usage

Type of compound

Carboxylic acid

Structural features

a. Cyclohexene ring
b. Propionic acid functional group

Applications

a. Intermediate in pharmaceutical production
b. Intermediate in agrochemical production
c. Synthesis of perfumes and fragrances

Biological activities

a. Antimicrobial properties
b. Anti-inflammatory properties

Versatility

Valuable in various chemical and pharmaceutical applications

Upstream product

• 186581-53-3 diazomethane 
• 84189-13-9 cyclohexene-1-acetyl chloride 
• 27338-40-5 cyclohex-1-enylmethyl-malonic acid 
• 823-45-0 2-(hydroxymethylene)cyclohexanone 
• 37677-17-1 1-bromomethylcyclohexene 
• 105-53-3 diethyl malonate 
• 74120-62-0 ethyl 3-(1'-hydroxycyclohexyl)propionate 
• 76925-79-6 1-<2-(carboethoxy)-ethynyl>cyclohexanol 
• 4845-04-9 1-cyclohexene-1-methanol 
• 18448-47-0 methyl cyclohex-1-ene-1-carboxylate 
• 67-63-0 isopropyl alcohol 
• 18294-87-6 1-cyclohexenylacetic acid 
• 65173-43-5 ethyl 3-(cyclohex-1-en-1-yl)propionate 
• 27338-39-2 diethyl (1-cyclohexenylmethyl)malonate 

Downstream Products

• 701-97-3 cyclohexanepropionic acid 
• 27338-45-0 (Cyclohexen-1')yl-3-propionsaeurechlorid 
• 197148-66-6 3-Cyclohex-1-enyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester 
• 22516-18-3 3-(cyclohex-1-en-1-yl)propan-1-ol 
• 63715-12-8 1-(3-mesyloxypropyl)-1-cyclohexene 
• 348135-81-9 1-(3-iodopropyl)cyclohex-1-ene 
• 389607-99-2 5-(1-cyclohexenyl)-pentanophenone 
• 389607-98-1 5-(1-cyclohexenyl)-pentanophenone N,N-dimethylhydrazone 
• 27338-46-1 Diazo-1-(cyclohexen-1')yl-4-butanon-2 
• 1488285-93-3 C₁₉H₂₃NO₂ 
• 749927-74-0 3-Cyclohex-1-enyl-thiopropionic acid S-pyridin-2-yl ester 

Relevant articles and documents

Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates

Ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non-biased 6-exo aza-Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction

The preparation of unsaturated secondary lactams via the palladium-catalyzed cyclization of O-phenyl hydroxamates onto a pendent alkene is reported. This method provides rapid access to a broad range of lactams that are widely useful building blocks in alkaloid synthesis. Mechanistic studies support an aza-Heck-type pathway.

Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: Discovery of deleobuvir (BI 207127)

Conformational restrictions of flexible torsion angles were used to guide the identification of new chemotypes of HCV NS5B inhibitors. Sites for rigidification were based on an acquired conformational understanding of compound binding requirements and the roles of substituents in the free and bound states. Chemical bioisosteres of amide bonds were explored to improve cell-based potency. Examples are shown, including the design concept that led to the discovery of the phase III clinical candidate deleobuvir (BI 207127). The structure-based strategies employed have general utility in drug design.