273384-78-4

Basic information

• Product Name: (RS)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE
• Synonyms: (RS)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(RS)-1-[2-(Trifluoromethyl)phenyl]ethylamine98%;1-(2-Trifluoromethylphenyl)ethylamine;1-[2-(Trifluoromethyl)phenyl]ethylamine, 2-(1-Aminoethyl)benzotrifluoride;alpha-Methyl-2-(trifluoromethyl)benzylamine 98%;alpha-Methyl-2-(trifluoromethyl)benzylamine98%;1-[2-(trifluoromethyl)phenyl]ethan-1-amine
• CAS NO: 273384-78-4
• Molecular Formula: C9H10F3N
• Molecular Weight: 189.18
• Product Categories: Amines and Anilines
• Mol File: 273384-78-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 68.7-71.1
• Flash Point: 78.8 °C
• Appearance: /
• Density: 1.18 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Water Solubility: at 25 deg C (mg/L): 4087
• CAS DataBase Reference: (RS)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(273384-78-4)
• EPA Substance Registry System: (RS)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(273384-78-4)

Safety Data

• Hazard Codes: Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• Hazardous Substances Data: 273384-78-4(Hazardous Substances Data)

Usage

General Description

The chemical compound "(RS)-1-[2-(trifluoromethyl)phenyl]ethylamine" is a chiral amine with the molecular formula C9H11F3N. It is composed of a trifluoromethyl group attached to a phenyl ring, which in turn is connected to an ethylamine group. (RS)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE is used in medicinal chemistry and drug discovery, particularly in the development of pharmaceuticals and biologically active compounds. Its trifluoromethyl group makes it an important building block for the synthesis of a wide range of pharmaceuticals, agrochemicals, and materials. Additionally, this compound can also be used as a reagent in organic synthesis and as a ligand in metal-catalyzed reactions.

Upstream product

• 79756-81-3 (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol 
• 17408-14-9 1-(2-(trifluoromethyl)phenyl)ethan-1-one 
• 127733-37-3 o-(trifluoromethyl)acetophenone O-methyloxime 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 865815-09-4 (S)-1-(2-(trifluoromethyl)phenyl)ethan-1-amine hydrochloride 
• 1332827-89-0 C₈H₆O₄*C₁₇H₁₈F₃N 
• 437762-07-7 (S)-1-phenyl-N-{(S)-1-[2-(trifluoromethyl)phenyl]ethyl}ethanamine 
• 444643-02-1 (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine 
• 39959-68-7 1-(2-(trifluoromethyl)phenyl)ethanamine hydrochloride 
• 1019534-81-6 C₁₆H₁₆F₃N 
• 1305329-57-0 C₁₆H₁₄F₃N 

Downstream Products

• 1332827-99-2 (S)-2,2,2-trifluoro-N-(1-(2-(trifluoromethyl)phenyl)ethyl)acetamide 
• 943779-22-4 C₃₇H₃₇F₃N₆O₃S 

Relevant articles and documents

Substituent effects on chiral resolutions of derivatized 1-phenylalkylamines by heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin GC stationary phase

Chiral resolutions of trifluoroacetyl-derivatized 1-phenylalkylamines with different type and position of substituent were investigated by capillary gas chromatography by using heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin diluted in OV-1701 as a chiral stationary phase. The influence of column temperature on retention and enantioselectivity was examined. All enantiomers of meta-substituted analytes as well as fluoro-substituted analytes could be resolved. Temperature had a favorable influence on enantioselectivity for small amines with substituents at the ortho-position. The type of substituent at the stereogenic center of amines also had a crucial effect as the ethyl group led to poor enantioseparation. Among all analytes studied, trifluoroacetyl-derivatized 1-(2′-fluorophenyl)ethylamine exhibited baseline resolution with the shortest analysis time.

PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS

Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Sequential reductive amination-hydrogenolysis: A one-pot synthesis of challenging chiral primary amines

Difficult-to-access chiral primary amines were formed in good to high yield and ee using a rare example of a one-pot synthesis from prochiral ketones (sequential reductive amination-hydrogenloysis). As a highlight we also demonstrate a one-pot reductive amination-hydrogenolysis-reductive amination (five reactions) of ortho-methoxyacetophenone resulting in the chiral diamine 1-(2-methoxyphenyl)ethyl-(2-pyridylmethyl)-amine (4) (58% overall yield, >99% ee), a new organocatalyst for aqueous enantioselective aldol reactions. Copyright