27361-14-4

Basic information

• Product Name: 1-Butyl-2(1H)-pyridinone
• Synonyms: 2(1H)-Pyridone,1-butyl- (8CI); 1-Butyl-2(1H)-pyridone; 1-Butyl-2-pyridone; N-Butyl-2-pyridone
• CAS NO: 27361-14-4
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Mol File: 27361-14-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 294.9°Cat760mmHg
• Flash Point: 135.7°C
• Appearance: /
• Density: 1g/cm³
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.501
• PKA: 0.31±0.20(Predicted)
• CAS DataBase Reference: 1-Butyl-2(1H)-pyridinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butyl-2(1H)-pyridinone(27361-14-4)
• EPA Substance Registry System: 1-Butyl-2(1H)-pyridinone(27361-14-4)

Safety Data

• Hazardous Substances Data: 27361-14-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H13NO/c1-2-3-7-10-8-5-4-6-9(10)11/h4-6,8H,2-3,7H2,1H3

Upstream product

• 142-08-5 2-hydroxypyridin 
• 109-65-9 1-bromo-butane 
• 85100-77-2 1-n-butyl-3-methylimidazolim bromide 
• 874-80-6 1-butylpyridinium bromide 
• 778-28-9 butyl para-toluenesulfonate 
• 542-69-8 1-iodo-butane 
• 109-69-3 n-Butyl chloride 
• 1628-89-3 2-methoxypyridine 
• 109-04-6 2-bromo-pyridine 
• 142-08-5 2-Pyridone 

Downstream Products

• 13200-29-8 1-Butyl-piperidin-2-thion 
• 82493-68-3 2-butyl-2-azabicyclo[2.2.0]hex-5-en-3-one 
• 82493-66-1 (1α,2β,5β,6α)-3,7-dibutyl-3,7-diazatricyclo[4.2.2.2^2,5]dodeca-9,11-diene-4,8-dione 
• 75608-94-5 5-methoxy-3-oxo-2-azabicyclo<2.2.0>hex-5-one 
• 82493-68-3 (1S,4R)-2-Butyl-2-aza-bicyclo[2.2.0]hex-5-en-3-one 
• 82493-66-1 (1α,2α,5α,6α)-3,7-dibutyl-3,7-diazatricyclo[4.2.2.2^2,5]dodeca-9,11-diene-4,8-dione 
• 873398-00-6 1-butyl-1H-pyridine-2-thione 
• 4789-08-6 1-Butyl 2-Piperidinone 
• 82535-45-3 (1R,2S,5R,6S)-3,8-Dibutyl-3,8-diaza-tricyclo[4.2.2.2^2,5]dodeca-9,11-diene-4,7-dione 
• 82493-69-4 (1S,2S,5R,6R)-3,8-Dibutyl-3,8-diaza-tricyclo[4.2.2.2^2,5]dodeca-9,11-diene-4,7-dione 

Relevant articles and documents

Microwave assisted rapid preparation of N-alkyl-2-pyridones under neutral conditions by Hilbert-Johnson reaction

The reactions of 2-methoxypyridine with haloalkanes without solvent and catalyst under microwave irradiation (100-200 °C, 5 min) yielded the corresponding N-alkyl-2(1H)-pyridones in good to moderate yields. However, the reactions were sensitive to length of haloalkanes. In contrast, the reactions of 2-alkoxypyridines with corresponding iodoalkanes under microwave irradiation (150 °C) proceeded rapidly without catalyst and solvent, and were complete within 5 min to afford N-alkyl-2(1H)-pyridones in good to excellent yields. The Japan Institute of Heterocyclic Chemistry.

Selective alkylation of 2-pyridone in solvent-free conditions

Alkylation of 2-pyridone has been performed in solvent-free conditions. The effect of base, phase transfer agent, and alkylation agent has been discussed.