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4-bromo-3-(hydroxymethyl)phenol is a chemical compound with the molecular formula C7H7BrO2. It is a derivative of phenol, containing a bromine atom and a hydroxymethyl group attached to the 3rd and 4th carbon atoms, respectively.

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  • 2737-20-4 Structure
  • Basic information

    1. Product Name: 4-bromo-3-(hydroxymethyl)phenol
    2. Synonyms: 4-bromo-3-(hydroxymethyl)phenol;2-bromo-5-hydroxy-benzyl alcohol
    3. CAS NO:2737-20-4
    4. Molecular Formula: C7H7BrO2
    5. Molecular Weight: 203.04
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2737-20-4.mol
  • Chemical Properties

    1. Melting Point: 142 °C
    2. Boiling Point: 341.2±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.722±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 9.17±0.18(Predicted)
    10. CAS DataBase Reference: 4-bromo-3-(hydroxymethyl)phenol(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-bromo-3-(hydroxymethyl)phenol(2737-20-4)
    12. EPA Substance Registry System: 4-bromo-3-(hydroxymethyl)phenol(2737-20-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2737-20-4(Hazardous Substances Data)

2737-20-4 Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-bromo-3-(hydroxymethyl)phenol is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals for its ability to be incorporated into various chemical structures.
Used in Organic Compound Production:
4-bromo-3-(hydroxymethyl)phenol is used as a building block in the production of other organic compounds, contributing to the formation of complex molecules.
Used as a Preservative in Consumer Products:
4-bromo-3-(hydroxymethyl)phenol has antimicrobial properties and is used as a preservative in various consumer products, such as cosmetics and personal care items, to prevent microbial growth and extend shelf life.
Safety Precautions:
It is important to handle 4-bromo-3-(hydroxymethyl)phenol with care, as it is considered harmful if swallowed, inhaled, or in contact with the skin, and can cause irritation to the eyes and respiratory system.

Check Digit Verification of cas no

The CAS Registry Mumber 2737-20-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,3 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2737-20:
(6*2)+(5*7)+(4*3)+(3*7)+(2*2)+(1*0)=84
84 % 10 = 4
So 2737-20-4 is a valid CAS Registry Number.

2737-20-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-5-hydroxybenzyl alcohol

1.2 Other means of identification

Product number -
Other names 2-bromo-5-hydroxy-benzyl alcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2737-20-4 SDS

2737-20-4Relevant articles and documents

Preparation method of benzoxaborole compound

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Paragraph 0232-0253, (2021/07/17)

The invention discloses a preparation method of a benzoxaborole compound. The preparation method comprises the following steps: (1) reacting raw materials containing halogenated hydrocarbon and boric acid ester under an alkaline condition, acidifying and hydrolyzing to obtain an intermediate VI; and (2) reacting a raw material containing the intermediate VI with halogenated cyanophenyl to obtain the benzoxaborole compound. The raw materials are low in price, the preparation cost of the benzoxaborole compound is reduced, the steps of protection and de-protection of organic groups are not needed in the preparation process, the reaction process is simplified, and yield reduction caused by group protection is avoided; and meanwhile, the method is mild in reaction condition, low in equipment requirement and easy for large-scale industrial production.

PNO ligand containing planar chiral ferrocene and application thereof

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Paragraph 0114-0118, (2021/06/21)

The invention discloses a PNO ligand containing planar chiral ferrocene and application thereof. The PNO ligand containing planar chiral ferrocene is a planar chiral ferrocene-containing and phenol-containing PNO ligand as shown in a general formula (I) or (II) which is described in the specification, or a planar chiral ferrocene-containing and aryl-phosphoric-acid-containingPNO ligand containing as shown in a general formula (III) or (IV) which is described in the specification, or a planar chiral ferrocene-containing and carbon-chiral-phenol-containingPNO ligand as shown in a general formula (V) or (VI) which is described in the specification. The invention provides tridentate PNO ligands and processes for their complexation with transition metal salts or transition metal complexes; the introduction of salicylaldehyde and derivatives thereof, which are simple and easy to obtain, enables the ligands to have a bifunctionalization effect, and -OH in a formed catalyst has stronger acidity and is beneficial to combination with N/O in polar double bonds. Therefore, due to the bifunctionalization effect of the catalyst, the interaction between the catalyst and a substrate can be greatly improved, so a reaction can obtain higher catalytic activity and stereoselectivity.

INTERMEDIATES AND PROCESS FOR THE PREPARATION OF A CRYSTALLINE FORM OF A TOPICAL ANTI-INFLAMMATORY AGENT

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Paragraph 0148, (2019/08/20)

The present invention relates to a process for the preparation of an inhibitor of phosphodiesterase 4, in particular of phosphodiesterase 4B (PDE4B), and intermediates useful for its preparation.

A substituted boron-containing compounds and pharmaceutical compositions containing the compounds (by machine translation)

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Paragraph 0128; 0130; 0131; 0132; 0133, (2019/02/02)

The present invention provides a substituted boron-containing compounds and containing the compound of the pharmaceutical composition and its use, the boron-containing compound of the formula (I) compounds, or their pharmaceutically acceptable salt, prodr

PROCESS FOR THE PREPARATION OF CRISABOROLE

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Paragraph 0039-0042, (2019/07/10)

The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):

IRIDIUM-BASED CATALYSTS FOR HIGHLY EFFICIENT DEHYDROGENATION AND HYDROGENATION REACTIONS IN AQUEOUS SOLUTION AND APPLICATIONS THEREOF

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Page/Page column 13; 15, (2018/11/22)

A series of iridium-based catalysts for dehydrogenation of formic acid, and hydrogenation using formic acid as the hydrogen source, and the process using the catalyst(s) to produce hydrogen gas from formic acid solution, or to reduce aldehydes using formic acid, are disclosed and claimed. More specifically, the present invention relates to a group of pentamethylcyclopentadienyl (Cp*) iridium complexes with different Ν,Ν-bidentate ligands that catalyze dehydrogenation from formic acid, and chemo-selective hydrogenation of aldehydes, in the aqueous solution system in a highly efficient, and long life-time manner.

Preparation method of boracic micromolecule

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Paragraph 0058-0060, (2018/12/14)

The invention discloses a preparation method of a boracic micromolecule 5-(4-cyanophenoxyl)-1,3-dihydro-1-hydroxy-2,1-benzodioxole. The preparation method includes the steps of (1) subjecting 2-bromine-5-hydroxybenzaldehyde to reduction reaction in solvent with the presence of reducing agents to obtain 2-bromine-5-hydroxybenzyl alcohol; (2) subjecting 2-bromine-5-hydroxybenzyl alcohol and a hydroxyl protection reagent to reaction in solvent with the presence of alkali; (3) subjecting the previous reactant to borate reaction in solvent under an alkaline condition; (4) removing hydroxyl protecting groups from the previous reactant to obtain a benzo[c][1,2]heterocyclopentadiene-1,5(3H)-glycol body; (5) subjecting the previous reactant to reaction in solvent under an alkaline condition to obtain a target object. The preparation method has the advantages of low cost of technological raw materials, easiness in obtaining of the technological raw materials, remarkably improved reaction yield,simplicity in operation, low cost and applicability to industrial production.

PROCESS FOR THE PREPARATION OF 5-(4-CYANOPHENOXY)-1,3-DIHYDRO-1-HYDROXY-[2,1]-BENZOXABOROLE AND POLYMORPHS THEREOF

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Page/Page column 20, (2018/12/13)

The present invention relates to process for the preparation of 5-(4-cyano phenoxy)-1,3-dihydro-1-hydroxy-[2, 1]-benzoxaborole represented by the following structural formula- 1 and polymorphs thereof. The present invention also relates to salts of 5-(4-cyano phenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and process for their preparation and their use in the preparation of pure compound of the formula- 1.

Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source

Yang, Zhanhui,Zhu, Zhongpeng,Luo, Renshi,Qiu, Xiang,Liu, Ji-Tian,Yang, Jing-Kui,Tang, Weiping

supporting information, p. 3296 - 3301 (2017/07/28)

A water-soluble highly efficient iridium catalyst is developed for the chemoselective reduction of aldehydes to alcohols in water. The reduction uses formic acid as the traceless reducing agent and water as a solvent. It can be carried out in air without the need for inert atmosphere protection. The products can be purified by simple extraction without any column chromatography. The catalyst loading can be as low as 0.005 mol% and the turn-over frequency (TOF) is as high as 73 800 mol mol-1 h-1. A wide variety of functional groups, such as electron-rich or deficient (hetero)arenes and alkenes, alkyloxy groups, halogens, phenols, ketones, esters, carboxylic acids, cyano, and nitro groups, are all well tolerated, indicating excellent chemoselectivity.

Boron-Containing Small Molecules as Anti-Inflammatory Agents

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Paragraph 0702-0703, (2015/11/16)

Compounds and methods of treating anti-inflammatory conditions are disclosed.

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