27382-53-2

Upstream product

• 104-94-9 4-methoxy-aniline 
• 134419-77-5 1-(2-bromophenyl)-3-phenylprop-2-yn-1-one 
• 2142-69-0 2-bromophenyl methyl ketone 
• 100-52-7 benzaldehyde 
• 108237-92-9 1-(2-bromophenyl)-3-phenylprop-2-en-1-one 
• 1169867-48-4 (Z)-1-(2-bromophenyl)-3-(4-methoxyanilino)-3-phenylprop-2-en-1-one 
• 1169867-74-6 (Z)-1-(2-chlorophenyl)-3-(4-methoxyanilino)-3-phenylprop-2-en-1-one 
• 27382-54-3 1-(4-methoxy-phenyl)-4-oxo-2-phenyl-1,4-dihydro-quinoline-3-carboxylic acid 
• 27382-52-1 2-acetylphenyl N-(4-methoxyphenyl)benzimidate 
• 27382-48-5 2'-[N-(p-methoxyphenyl)-amino]-2-(methyl-sulphinyl)-acetophenone 

Downstream Products

• 27382-45-2 1-(4-methoxyphenyl)-2-phenyl-1,2,3,4-tetrahydroquinoline 

Relevant academic research and scientific papers

Buchwald-Hartwig coupling/Michael addition reactions: One-pot synthesis of 1,2-disubstituted 4-quinolones from chalcones and primary amines

The Buchwald-Hartwig coupling/Michael addition sequence has been successfully applied to the synthesis of functionalized 1,2-disubstituted 4-quinolones using Pd(OAc)2 as a catalyst and PPh3 as a ligand. Under these conditions, the intermediate products first formed from chalcones and primary amines underwent catalytic dehydrogenation to yield the 1,2-disubstituted 4-quinolones. Copyright

Palladium-catalyzed tandem amination reaction for the synthesis of 4-quinolones

(Figure presented) An efficient palladium-catalyzed tandem amlnatlon approach was developed In one step to afford functlonallzed 4-qulnolones In good to excellent ylelds from easlly accessible o-haloaryl acetylenlc ketones and primary amines.

1,2-Disubstituted 4-quinolones via copper-catalyzed cyclization of 1-(2-halophenyl)-2-en-3-amin-1-ones

1,2-Disubstituted 4-quinolones have been prepared via copper-catalyzed heterocyclization of 1-(2-bromophenyl)- and 1-(2-chlorophenyl)-2-en-3-amin-1- ones, readily obtained from α,β-ynones and primary amines. The reaction tolerates a variety of useful functionalities including ester, keto, cyano, and chloro substituents. Quinolone derivatives can also be prepared via a sequential process from α,β-ynones and primary amines, omitting the isolation of the 1-(2-halophenyl)-2-en-3-amin-1-one intermediates. Georg Thieme Verlag Stuttgart.

3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols

The invention relates to novel 1-(4-R1 O-phenyl)-2-(4-R2 -phenyl)-6-R3 -1,2,3,4-tetrahydroquinolines having anti-fertility and hypocholesterolemic activities, to their preparation, and to novel intermediates therefor.