27386-01-2

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 4649, 1956 DOI: 10.1021/ja01599a033

InChI:InChI=1/C3H5N3S2/c1-4-2-5-6-3(7)8-2/h1H3,(H,4,5)(H,6,7)

Upstream product

• 140-89-6 potassium ethyl xanthogenate 
• 6610-29-3 4-methylthiosemicarbazide 
• 38451-14-8 1,6-dimethyl-2,5-dithiobiurea 
• 75-15-0 carbon disulfide 

Downstream Products

• 27386-03-4 4-benzyl-5-methylamino-2,4-dihydro-[1,2,4]triazole-3-thione 
• 27391-62-4 N-benzyl-N'-methyl-[1,3,4]thiadiazole-2,5-diamine 
• 21111-48-8 5-methylamino-4-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 21123-49-9 N-methyl-N'-phenyl-[1,3,4]thiadiazole-2,5-diamine 
• 65373-29-7 N-(5-benzylsulfanyl-[1,3,4]thiadiazol-2-yl)-methylamine 
• 97773-03-0 2-(3-fluorobenzylthio)-5-methylamino-1,3,4-thiadiazole 

Relevant academic research and scientific papers

Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents

Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are major problems in chemotherapy. Nowadays the aim of many medical research projects is to discover new safer and more effective anticancer agents. 1,3,4-Thiadiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities, including anticancer activities. The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds as chemotherapeutic agents. The structures of the obtained compounds were elucidated using 1H-NMR, 13C-NMR and mass spectrometry. Although the thiadiazole derivatives did not prove to be significantly cytotoxic to the tumour tissue cultures, compound 4i showed activity against the C6 rat brain cancer cell line (IC50 0.097 mM) at the tested concentrations.

Cephalosporin derivatives and bactericides containing the same

Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: STR1 wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); STR2 or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): STR3 or an unsubstituted or substituted pyridinium group of a formula (I-3); STR4 or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):

Process for the production of 2-amino-5-mercapto-1,3,4-thiadiazole

2-Amino-5-mercapto-1,3,4-thiadiazoles can be produced in very high yields from thiosemicarbazides and carbon disulfide in aqueous phase by working in the presence of the corresponding ammonium salt of bis-2,5-mercapto-1,3,4-thiadiazole at a temperature above 40° C. Preferably the process is carried out in the presence of the mother liquor from a previous reaction.

Process for producing 2-amino or selected 2-(substituted)amino-5-mercapto-1,3,4-thiadiazole compounds

Disclosed is a process for producing 2-amino or 2-(lower alkyl or phenyl)amino-5-mercapto-1,3,4-thiadiazole compounds by reacting the corresponding thiosemicarbazide with an alkali metal lower alkyl xanthate salt.

Synergistic herbicidal compositions

Synergistic herbicidal compositions are provided, containing as active ingredients: (1) 3-(benzthiazol-2-yl)-1,3-dimethyl-urea of the formula STR1 and (2) 3-(5-n-butylsulphonyl-1,3,4-thiadiazol-2-yl)-1,3-dimethyl-urea of the formula STR2 alone or in admixture with a solid or liquid or liquefied gaseous diluent or carrier.