65373-29-7

Usage

Uses

Used in Pharmaceutical Industry:
5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE is used as a GPR171 antagonist for its anxiolytic and anti-fear conditioning properties. It has been shown to reduce anxiety-like behavior and fear conditioning in mice, making it a promising candidate for the development of novel treatments for anxiety disorders and related conditions.
Used in Neuroscience Research:
In addition to its potential therapeutic applications, 5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE can also be utilized in neuroscience research to better understand the role of GPR171 receptors in anxiety and fear-related behaviors. This knowledge can contribute to the development of more targeted and effective treatments for these conditions.

Upstream product

• 27386-01-2 5-methylamino-3H-[1,3,4]thiadiazole-2-thione 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 27386-01-2 2-methylamino-5-mercapto-1,3,4-thiadiazole 
• 96989-50-3 di-2-pyridyl thionocarbonate 
• 74-89-5 methylamine 
• 34725-32-1 1-methyl-2,5-dithiobiurea 

Downstream Products

• 109046-37-9 N-(benzylmercapto-[1,3,4]thiadiazol-2-yl)-N-methyl-acetamide 
• 65373-23-1 1-(5-Benzylthio-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea 

Relevant academic research and scientific papers

Versatile strategies for the solid phase synthesis of small heterocyclic scaffolds: [1,3,4]-Thiadiazoles and [1,3,4]-oxadiazoles

New robust protocols for the solid phase synthesis of 5-alkylthio-, 5-alkyl/aryl-, and 5-acylamino-2-alkylamino-[1,3,4]-thiadiazoles are described based on a common resin bound thiosemicarbazide. A protocol for the solid phase synthesis of 2-alkyl/aryl-amino-5-alkylamino-[1,3,4]-oxadiazoles from a resin bound semicarbazide is likewise reported. The protocols have been verified by the preparation of four small libraries that all gave products in good to excellent yields and purity.

Oxidation and Eliminative Cyclisation of S-Alkylisodithiobiureas

Isothiocyanates condense with S-alkylisothiosemicarbazides to yield S-alkylisodithiobiureas.These undergo cyclisation to give 3-amino-5-mercapto-4-substituted-1,2,4-triazoles with the elimination of alkyl mercaptan on heating under neutral conditions, whereas under acidic conditions, by elimination of ammonia 5-alkylmercapto-2-substituted amino-1,3,4-thiadiazoles are formed.Condensation of isothiocyanates with thiosemicarbazides in the presence of alkali affords 1-substituted dithiobiureas.Alkylation of these dithiobiureas with alkyl halides results in the formation of 5-alkylmercapto-2-substituted-amino-1,3,4-thiadiazoles, any intermediateproduct not being isolable.On the other hand, oxidation of 1-substituted dithiobiureas with either hydrogen peroxide or iodine furnishes 2-amino-5-substituted-amino-1,3,4-thiadiazoles.

Combating weeds in soybeans

Weeds are selectively controlled in soybean fields by post-emergent application of a compound having the structural formula STR1 in which X represents bromo, fluoro, cyano or trifluoromethyl and R is hydrogen or methyl.