27392-71-8

Basic information

• Product Name: 1-(6-amino-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one
• Synonyms: 1-(6-amino-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one
• CAS NO: 27392-71-8
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.24166
• Mol File: 27392-71-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 477.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.182±0.06 g/cm3(Predicted)
• PKA: 3.78±0.20(Predicted)
• CAS DataBase Reference: 1-(6-amino-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-amino-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one(27392-71-8)
• EPA Substance Registry System: 1-(6-amino-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one(27392-71-8)

Safety Data

• Hazardous Substances Data: 27392-71-8(Hazardous Substances Data)

Upstream product

• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 75-36-5 acetyl chloride 
• 157589-45-2 N-(1,2,3,4-tetrahydro-6-quinolyl)trifluoroacetamide 
• 157589-44-1 N-(6-quinolyl)trifluoroacetamide 
• 580-15-4 6-aminoquinoline 
• 158942-58-6 N-(1-acetyl-1,2,3,4-tetrahydro-6-quinolyl)trifluoroacetamide 
• 4138-40-3 N-allyl-p-nitroaniline 
• 14026-46-1 1-(1,2,3,4-tetrahydro-6-nitroquinolinyl)ethanone 
• 14026-45-0 6-nitro-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

HEAT SHOCK PROTEIN 90 INHIBITORS

Substituted aromatic compounds of formula (I) shown below: (formula I) The definition of each variable in formula (I) appears in the Specification. Also disclosed is a pharmaceutical composition containing one of the substituted aromatic compounds. Further disclosed is a method of using one of these compounds for treating a medical condition associated with HSP90.

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrroloindole: A Novel 5-HT2C/5-HT2B Receptor Antagonist with Improved Affinity, Selectivity, and Oral Activity

The preparation of a series of conformationally restricted analogues of indolylurea 1, namely tetrahydropyrroloindoles and tetrahydropyrroloquinolines, is described.The binding affinities of these compounds at 5-HT2A, 5-HT2B, and 5-HT2C receptors were determined.Of these compounds, the 1,2,3,5-tetrahydropyrroloindole derivative, compound 11, was found to have high affinity for the 5-HT2C (pK1 8.0) and 5-HT2B receptors (pA2 8.5), with excellent selectivity over the 5-HT2A and various other receptors (pK1B 8.8), and an in vivo functional model, mCPP-induced hypolocomotion (ID50 5.5 mg/kg po). 11 should therefore be of significant utility as a pharmacological tool to delineate the functional significance of blockade of 5-HT2B and 5-HT2C receptors.