27395-93-3Relevant articles and documents
Photophysical and thermal properties of novel solid state fluorescent benzoxazole based styryl dyes from a DFT study
Yadav, Urmiladevi Narad,Kumbhar, Haribhau Shantaram,Deshpande, Saurabh Satish,Sahoo, Suban Kumar,Shankarling, Ganapati Subray
, p. 42971 - 42977 (2015)
Novel benzoxazole styryl dyes 6a-6e with donor(D)-π(pi)-acceptor(A) were synthesized and characterized. The spectral (absorption and emission) and thermogravimetric properties of the dyes were investigated. They were found to possess red-shifted absorption with a high molar extinction coefficient when compared to their reported analogues. The compounds exhibited enhanced fluorescence emission in the solid state (540-603 nm). They showed excellent thermal and photochemical stability. The effect of the benzoxazole moiety on the photophysical properties is explained by comparing with reported analogues and density functional theory (DFT) calculations. Thus investigations of photophysical properties provide an important foundation for the molecular design and development of novel optoelectronic materials for OLED and NLO applications.
Bimetallic Cooperative Catalysis for Decarbonylative Heteroarylation of Carboxylic Acids via C-O/C-H Coupling
Liu, Chengwei,Ji, Chong-Lei,Zhou, Tongliang,Hong, Xin,Szostak, Michal
supporting information, p. 10690 - 10699 (2021/04/09)
Cooperative bimetallic catalysis is a fundamental approach in modern synthetic chemistry. We report bimetallic cooperative catalysis for the direct decarbonylative heteroarylation of ubiquitous carboxylic acids via acyl C-O/C-H coupling. This novel catalytic system exploits the cooperative action of a copper catalyst and a palladium catalyst in decarbonylation, which enables highly chemoselective synthesis of important heterobiaryl motifs through the coupling of carboxylic acids with heteroarenes in the absence of prefunctionalization or directing groups. This cooperative decarbonylative method uses common carboxylic acids and shows a remarkably broad substrate scope (>70 examples), including late-stage modification of pharmaceuticals and streamlined synthesis of bioactive agents. Extensive mechanistic and computational studies were conducted to gain insight into the mechanism of the reaction. The key step involves intersection of the two catalytic cycles via transmetallation of the copper–aryl species with the palladium(II) intermediate generated by oxidative addition/decarbonylation.
Novel benzoxazole derivatives featuring rhodanine and analogs as antihypergycemic agents: synthesis, molecular docking, and biological studies
Singh, Varinder,Singh, Amanjot,Singh, Gagandeep,Verma, Raman K.,Mall, Rajiv
, p. 735 - 743 (2017/10/25)
A novel series of benzoxazolyl linked benzylidene based rhodanine and their cyclic analogs were synthesized, characterized and evaluated for their α-amyloglucosidase inhibitory activity. Out of eight target compounds, two compounds (4b and 5b) displayed potent inhibitory activity against α-amyloglucosidase with IC50 values in the range of 0.24 ± 0.01–0.94 ± 0.01 μM as compared to standard drug acarbose. Among all the tested compounds, compound 5b containing rhodanine at 3-position of phenyl was found to be the most active inhibitor of α-amyloglucosidase. Docking studies showed the existence of potential H-bonding interactions between synthesized compounds and α-glucosidase which might be responsible for good biological activity.
