27402-31-9Relevant articles and documents
Low transition temperature mixtures prompted one-pot synthesis of 5, 10 dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione derivatives
Mohire, Priyanka P.,Patil, Reshma B.,Chandam, Dattatraya R.,Jadhav, Sunetra J.,Patravale, Ajinkya A.,Kumbhar, Digambar R.,Ghosh, Jai S.,Deshmukh, Madhukar B.
, p. 7013 - 7028 (2017)
Abstract: An efficient green protocol has been investigated for the synthesis of pyrimido[4,5-b]quinolines derivatives via one-pot three-component condensation of 4-chloro aniline, aromatic aldehyde and barbituric acid using low transition temperature mixtures as new generation and sustainable solvents. The process was accomplished with the use of greener and recyclable reaction media, simple methodology, easy workup procedures and no chromatographic purification with high yield. This new approach is expected to discover some significance in combinatorial synthesis of biologically active scaffolds.
One-pot three component cascade synthesis of fused ring quinazoline-2,4-dione derivatives employing heterocyclic ketene aminals as a versatile synthone
Yaqub, Muhammad,Arif, Nadia,Perveen, Ruqayia,Batool, Javaria,Riaz, Muhammad Tariq,Yaseen, Muhammad
, p. 1013 - 1018 (2015)
One-pot three component cascade protocol for the synthesis of quinazoline-2,4-dione derivatives was designed and a series of twenty fused ring quinazoline-2,4-dione derivatives 11a-11j and 12a-12j were synthesized by the reaction of heterocyclic ketene am
Nanosized calcined mixed oxides-supported alkali metal (K2O/Al2O3–CaO) as solid base catalyst: preparation and investigation of its catalytic efficiency in the synthesis of benzylidene malononitriles/barbiturates and in pyrano[2,3-d]pyrimidines
Chowhan, Bushra,Gupta, Monika,Sharma, Neha,Vaid, Rupali
, (2022/02/14)
Potassium impregnated over mixed oxides (K2O/Al2O3–CaO) as solid base catalyst was synthesized and characterized by various techniques such as FTIR, TGA, XRD, TEM, SAED, SEM and XPS. It efficiently catalyzed the one-pot Knoevenagel/Michael condensation to form derivatives of pyrano[2,3-d]pyrimidine and benzylidene malononitrile derivatives, benzylidene barbituric acid derivatives by Knoevenagel condensation which were isolated and characterized by 1H-NMR and 13C-NMR. The catalyst was recyclable up to five runs without any significant loss in activity. Graphical abstract: [Figure not available: see fulltext.]
Knoevenagel condensation in aqueous media promoted by 2,2′-bipyridinium dihydrogen phosphate as a green efficient catalyst
Darvishzad, Shila,Daneshvar, Nader,Shirini, Farhad,Tajik, Hassan
, p. 2973 - 2984 (2021/04/19)
A 2,2′-Bipyridine-based ionic compound named 2,2′-bipyridinium dihydrogen phosphate was synthesized by addition of phosphoric acid to a solution of 2,2′-Bipyridine in dichloromethane. After the characterization using FT-IR, mass, 1H, 13C and 31P NMR techniques, it was used as a Bronsted dicationic acidic catalyst for the promotion of the synthesis of 2-arylidene malononitrile and 5-arylidene barbituric acid derivatives via Knoevenagel condensation reaction in water. Some of the advantages of this method are the utilization of an easy preparable, cost-effective and eco-friendly organic salt as a catalyst within high rates and yields of the reactions, simple and quick work-up and acceptable reusability of the catalyst.
