27404-31-5

Basic information

• Product Name: 2-BENZO[B]FURAN-3-YLETHYLAMINE
• Synonyms: 2-BENZO[B]FURAN-3-YLETHYLAMINE;2-Benzo[b]furan-3-ylethylamine 97%;3-Benzofuranethanamine;2-(benzofuran-3-yl)ethanamine;3-(Aminoethyl)benzo[b]furan 97%;2-(1-Benzofuran-3-yl)ethylamine, 2-(Benzo[b]furan-3-yl)ethylamine, 3-(Aminoethyl)-1-benzofuran;2-(1-benzofuran-3-yl)ethan-1-aMine;2-Benzofuran-3-yl-ethylaMine
• CAS NO: 27404-31-5
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 27404-31-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 183-185 °C
• Boiling Point: 268.529 °C at 760 mmHg
• Flash Point: 116.202 °C
• Appearance: /
• Density: 1.129 g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.71±0.10(Predicted)
• CAS DataBase Reference: 2-BENZO[B]FURAN-3-YLETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZO[B]FURAN-3-YLETHYLAMINE(27404-31-5)
• EPA Substance Registry System: 2-BENZO[B]FURAN-3-YLETHYLAMINE(27404-31-5)

Safety Data

• Hazardous Substances Data: 27404-31-5(Hazardous Substances Data)

Usage

General Description

2-Benzo[b]furan-3-ylethylamine, also known as 2-BF-3-YL-EA, is a chemical compound with a molecular formula of C12H13NO. It is a derivative of the benzofuran class of compounds and consists of a benzofuran ring fused to an ethylamine group. This chemical is not widely studied in the scientific literature, but it is known to have potential psychoactive or central nervous system effects. It may have implications for drug discovery and medicinal chemistry research, particularly in the development of new drugs targeting neurotransmitter systems in the brain. Further research is needed to fully understand the properties and potential applications of 2-Benzo[b]furan-3-ylethylamine.

InChI:InChI=1/C10H11NO/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7H,5-6,11H2

Upstream product

• 21535-97-7 3-methyl-benzofuran 
• 1878-62-2 2-(2-acetylphenoxy)acetic acid 
• 63815-27-0 2-(2'-acetylphenoxy)acetic acid ethyl ester 
• 441055-15-8 (rac)-2-acetylamino-3-benzofuran-3-yl-propionic acid 
• 1023290-69-8 2-acetylamino-2-benzofuran-3-yl-methyl-malonic acid diethyl ester 
• 118-93-4 o-hydroxyacetophenone 
• 67713-99-9 (benzofuran-3-yl)methyl chloride 
• 7169-34-8 3-oxo-2,3-dihydrobenzo[b]furan 
• 52407-43-9 3-cyanomethylbenzo[b]furan 
• 4687-23-4 3-hydroxymethylbenzofuran 
• 4687-25-6 1-benzofuran-3-carbaldehyde 
• 27404-32-6 N-2-(benzo[b]furan-3-yl)ethylamine hydrochloride 

Downstream Products

• 67714-01-6 1-methyl-3,4-dihydrobenzofuro[2,3-c]pyridine 
• 906344-96-5 5-bromofuran-2-carboxylic acid (2-benzofuran-3-yl-ethyl)-amide 
• 629662-33-5 6,7-dihydro-5H-10-oxa-7-azabenzo[a]azulene-9-carboxylic acid ethyl ester 
• 1160484-75-2 naphthalen-2-ylmethyl2-(benzofuran-3-yl)ethylcarbamodithioate 
• 1569976-46-0 methyl 4-(1-(2-(benzofuran-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate 

Relevant articles and documents

Substrate-Tuned Catalysis of the Radical S-Adenosyl- L -Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis

NosL is a radical S-adenosyl-L-methionine (SAM) enzyme that converts L-Trp to 3-methyl-2-indolic acid, a key intermediate in the biosynthesis of a thiopeptide antibiotic nosiheptide. In this work we investigated NosL catalysis by using a series of Trp analogues as the molecular probes. Using a benzofuran substrate 2-amino-3-(benzofuran-3-yl)propanoic acid (ABPA), we clearly demonstrated that the 5′-deoxyadenosyl (dAdo) radical-mediated hydrogen abstraction in NosL catalysis is not from the indole nitrogen but likely from the amino group of L-Trp. Unexpectedly, the major product of ABPA is a decarboxylated compound, indicating that NosL was transformed to a novel decarboxylase by an unnatural substrate. Furthermore, we showed that, for the first time to our knowledge, the dAdo radical-mediated hydrogen abstraction can occur from an alcohol hydroxy group. Our study demonstrates the intriguing promiscuity of NosL catalysis and highlights the potential of engineering radical SAM enzymes for novel activities.

N-phenpropylcuclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase

The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, —NR2 R3 or —NR4SO2R5; X is the linkage —(CH2)n— or —(CH2)q—O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.

Design and Synthesis of Benzofuranic Derivatives as Potential Inhibitors of Hydroxyindole-O-methyltransferase

-