63815-27-0

Basic information

• Product Name: ethyl 2-(2-acetylphenoxy)acetate
• Synonyms: ethyl 2-(2-acetylphenoxy)acetate;(2-Acetyl-phenoxy)-acetic acid ethyl ester
• CAS NO: 63815-27-0
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.24
• Mol File: 63815-27-0.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(2-acetylphenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-acetylphenoxy)acetate(63815-27-0)
• EPA Substance Registry System: ethyl 2-(2-acetylphenoxy)acetate(63815-27-0)

Safety Data

• Hazardous Substances Data: 63815-27-0(Hazardous Substances Data)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 105-39-5 chloroacetic acid ethyl ester 
• 623-50-7 ethyl 2-hydroxyacetate 
• 105-36-2 ethyl bromoacetate 
• 64-17-5 ethanol 
• 1878-62-2 2-(2-acetylphenoxy)acetic acid 

Downstream Products

• 21535-97-7 3-methyl-benzofuran 
• 24673-56-1 3-methyl-1-benzofuran-2-carboxylic acid 
• 62557-53-3 2,3,4,5-tetrahydro-1-benzoxepine-3,5-dione 
• 1878-62-2 2-(2-acetylphenoxy)acetic acid 
• 137514-49-9 Ethyl cis-3-hydroxy-3-methyl-2,3-dihydro-2-benzofuryncarboxylate 
• 137514-49-9 Ethyl trans-3-hydroxy-3-methyl-2,3-dihydro-2-benzofuryncarboxylate 
• 22367-82-4 ethyl 3-methyl-1-benzofuran-2-carboxylate 
• 168918-50-1 (E)-3-(2-Ethoxycarbonylmethoxy-phenyl)-but-2-enoic acid ethyl ester 
• 4687-23-4 3-hydroxymethylbenzofuran 
• 4687-25-6 1-benzofuran-3-carbaldehyde 
• 67713-99-9 (benzofuran-3-yl)methyl chloride 
• 23911-56-0 2-acetyl-3-methylbenzofuran 
• 67382-14-3 2-Bromo-1-(3-methylbenzofuran-2-yl)ethanone 
• 27404-31-5 2-(benzofuran-3-yl)ethanamine 

Relevant articles and documents

Bi(OTf)3-Mediated (4+1) Annulation of α-Sulfonyl o-Hydroxyacetophenones with α-Hydroxy Arylketones to Access Sulfonyl 2-Aroylbenzofurans

In this paper, a high-yield, facile route for the scalable synthesis of sulfonyl 2-aroylbenzofurans via a Bi(OTf)3-mediated intermolecular double cyclocondensation of α-sulfonyl o-hydroxyacetophenones with substituted α-hydroxy arylketones under mild open-vessel reaction conditions is described. In the overall reaction, water is generated as the only byproduct. Various metal triflate-promoted reactions and conditions are investigated for the efficient one-pot (4+1) annulation reaction. (Figure presented.).

4-Hydroxy-3-methylbenzofuran-2-carbohydrazones as novel LSD1 inhibitors

Histone lysine specific demethylase 1 (LSD1 or KDM1A) is a potential therapeutic target in oncology due to its overexpression in various human tumors. We report herein a new class of benzofuran acylhydrazones as potent LSD1 inhibitors. Among the 31 compounds prepared, 14 compounds exhibited excellent LSD1 inhibitory activity with IC50 values ranging from 7.2 to 68.8 nM. In cellular assays, several compounds inhibited the proliferations of various cancer cell lines, including PC-3, MCG-803, U87 MG, PANC-1, HT-29 and MCF-7. This opens up the opportunity for further optimization and investigation of this class compounds for potential cancer treatment.

Mercapto-amide boronic acid derivative and application thereof as MBL (metal beta-lactamase) and/or SBL (serine beta-lactamase) inhibitor

The invention provides a compound of a formula (I) shown in the specification, or a conformational isomer, or an optical isomer or a pharmaceutically acceptable salt thereof. The compound of the formula (I) shown in the specification has excellent broad-spectrum inhibitory activity on MBL (metal beta-lactamase) and/or SBL (serine beta-lactamase), and can be used for preparing MBL and/or SBL inhibitors. Moreover, the compound disclosed by the invention has excellent antibacterial activity on multiple drug-resistant bacteria and is capable of reversing drug resistance of carbapenem drug-resistant bacteria, and the antibacterial effect of the compound is prior to those of positive control products such as L-captopril and tazobactam. The compound disclosed by the invention has very great potential in preparation of MBL/SBL dual inhibitors and medicines reversing drug resistance of carbapenem drug-resistance bacteria.