67713-99-9Relevant academic research and scientific papers
Boronic acid derivatives
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Paragraph 0098; 0105-0108, (2021/07/21)
The present invention relates to boronic acid derivatives; the present invention provides compounds of formula (I) or pharmaceutically acceptable salts, solvates, polymorphs or isomers thereof, pharmaceutical compositions comprising these compounds, and u
Boronic acid derivatives
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Paragraph 0113; 0120-0123, (2021/07/21)
The present invention relates to boronic acid derivatives; the present invention provides compounds of formula (I) or pharmaceutically acceptable salts, solvates, polymorphs or isomers thereof, pharmaceutical compositions comprising these compounds, and uses of such compounds in the treatment of lmp7-related diseases.
Synthesis of 3H-[1]Benzofuro[2,3-b]imidazo[4,5-f]quinolines as New Fluorescent Heterocyclic Systems for Dye-Sensitized Solar Cells
Sadeghzadeh,Pordel,Davoodnia
, p. 440 - 447 (2021/04/13)
Abstract: One-pot reaction of 1-alkyl-5-nitro-1H-benzimidazoles with 2-(1-benzofuran-3-yl)acetonitrile in methanol in the presence of potassium hydroxide gave 3H-[1]benzofuro[2,3-b]imidazo[4,5-f]quinolines as high-performance organic photosensitizers belonging to a new fluorescent heterocyclic system. The structure of the new compounds was assigned on the basis of their spectral and analytical data. Study of the optical properties of the title compounds revealed their interesting photophysical properties such as high fluorescence quantum yields. Their electrochemical properties were studied by cyclic voltammetry, and reversible oxidation waves were observed. The photovoltaic performance of the fluorescent heterocyclic compounds was estimated at 4.89–5.05% from the IPCE spectra and I–V curves.
Method for synthesizing 3 - halo methyl benzofuran compounds
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Paragraph 0028; 0029; 0030; 0031, (2019/03/21)
The invention provides a method for efficiently synthesizing a 3-halomethylation benzofuran class compound by one step through a 2-propargyloxy aniline class compound. Compared with an existing method, the method can adapt to substrates for a wide range, the compound is convenient and easy to obtain, the reaction condition is mild, the operation is easy and convenient, and the reaction efficiency is high. By means of the method, metal salt compounds do not need to be added, and the production and processing for drugs are facilitated.
IMMUNOPROTEASOME INHIBITORS
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Paragraph 0399; 0400, (2019/06/13)
Provided herein are compounds, such as a compound of Formula (I), or a pharmaceutically acceptable salt thereof, that are immunoproteasome (such as LMP2 and LMP7) inhibitors. The compounds described herein can be useful for the treatment of diseases treatable by inhibition of immunoproteasomes. Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
Chromium-Catalyzed Asymmetric Dearomatization Addition Reactions of Halomethyl Heteroarenes
Tian, Qingshan,Bai, Jing,Chen, Bin,Zhang, Guozhu
supporting information, p. 1828 - 1831 (2016/05/19)
The first asymmetric dearomatization addition reaction of halomethyl arenes including benzofuran and benzothiophene was enabled by chromium catalysis. A variety of aldehydes served as suitable electrophiles under mild reaction conditions. Molecular complexities are quickly increased in a highly diastereo- and enantioselective manner.
Substrate-Tuned Catalysis of the Radical S-Adenosyl- L -Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis
Ji, Xinjian,Li, Yongzhen,Ding, Wei,Zhang, Qi
supporting information, p. 9021 - 9024 (2015/08/03)
NosL is a radical S-adenosyl-L-methionine (SAM) enzyme that converts L-Trp to 3-methyl-2-indolic acid, a key intermediate in the biosynthesis of a thiopeptide antibiotic nosiheptide. In this work we investigated NosL catalysis by using a series of Trp analogues as the molecular probes. Using a benzofuran substrate 2-amino-3-(benzofuran-3-yl)propanoic acid (ABPA), we clearly demonstrated that the 5′-deoxyadenosyl (dAdo) radical-mediated hydrogen abstraction in NosL catalysis is not from the indole nitrogen but likely from the amino group of L-Trp. Unexpectedly, the major product of ABPA is a decarboxylated compound, indicating that NosL was transformed to a novel decarboxylase by an unnatural substrate. Furthermore, we showed that, for the first time to our knowledge, the dAdo radical-mediated hydrogen abstraction can occur from an alcohol hydroxy group. Our study demonstrates the intriguing promiscuity of NosL catalysis and highlights the potential of engineering radical SAM enzymes for novel activities.
Carbolithiation of chloro-substituted alkynes: A new access to vinyl carbenoids
Lhermet, Rudy,Ahmad, Maha,Fressigne, Catherine,Silvi, Bernard,Durandetti, Muriel,Maddaluno, Jacques
, p. 10249 - 10254 (2014/08/18)
The intramolecular carbolithiation of a series of chloro-substituted alkynes leads to exocyclic alkylidene carbenoids of which both nucleophilic and electrophilic characters can be drove. A sole stereoselective 5-exo-dig addition takes place, probably bec
Preparation and reactions of heteroarylmethylzinc reagents
Barl, Nadja M.,Sansiaume-Dagousset, Elodie,Monzon, Gabriel,Wagner, Andreas J.,Knochel, Paul
supporting information, p. 2422 - 2425 (2014/05/20)
We report a general preparation of heteroarylmethylzinc chlorides by direct zinc insertion into heteroarylmethyl chlorides, along with a facile and straightforward synthesis of these heterocyclic chloromethyl precursors. We demonstrate that heteroarylmethylzinc reagents undergo various reactions including cross-couplings, allylations, acylations, and addition reactions to aldehydes, leading to polyfunctional heterocyclic products. Furthermore, these heteroaromatic zinc compounds prove to be versatile reagents for the preparation of various N- and O-heterocycles and give access to an analogue of a CB1 modifier.
Chemoenzymatic preparation of enantiopure l-benzofuranyl- and l-benzo[b]thiophenyl alanines
Podea, Paula Veronica,Tosa, Monica Ioana,Paizs, Csaba,Irimie, Florin Dan
, p. 500 - 511 (2008/09/19)
Lipase mediated DKR followed by a chemical and an enzymatic hydrolytic step were combined for the synthesis of enantiopure l-benzofuranyl- and l-benzothienyl alanines.
