2741-14-2

Usage

Uses

Used in Pharmaceutical Research:
3-Benzyl-1,1-dimethylthiourea is utilized as a reagent in organic synthesis and pharmaceutical research. Its antioxidant and anti-inflammatory properties make it a promising candidate for the development of new drugs to treat various medical conditions.
Used in Neurodegenerative Disease Treatment:
In the medical field, 3-benzyl-1,1-dimethylthiourea is studied for its potential applications in the treatment of neurodegenerative diseases. Its capacity to exhibit neuroprotective effects positions it as a candidate for further research and development in this area.
Used in Cancer Treatment:
Additionally, 3-benzyl-1,1-dimethylthiourea has been investigated for its potential role in cancer treatment. 3-benzyl-1,1-dimethylthiourea's properties are being explored to understand its impact on cancer cells and its possible use in therapeutic strategies against cancer.

Upstream product

• 622-78-6 Benzyl isothiocyanate 
• 124-40-3 dimethyl amine 
• 137-26-8 Thiram 
• 100-46-9 benzylamine 

Downstream Products

• 1329430-18-3 N'-benzyl-N,N-dimethyl-2-phenylsulfanyl-benzamidine 

Relevant academic research and scientific papers

Insertion of arynes into thioureas: A new amidine synthesis

Arynes, generated from trimethylsilyl phenyltriflate precursors, have been found to react with thioureas via a formal π-insertion into the C=S bond. The reaction contrasts with that of ureas, which proceeds via benzyne σ-insertion into the C-N bond, and r

Thiocarbamoylation of amine-containing compounds 5. The mechanism of reactions of tetramethylthiuram disulfide with aliphatic amines

Thiocarbamoylation of aliphatic amines with tetramethylthiuram disulfide (TMTD) was studied. The reactions were established to proceed according to a two-stage mechanism. In the first stage, S-(thiocarbamoyl)thiohydroxylamines and dimethyl dithiocarbamates are formed. The latter exist in equilibrium with dimethyldithiocarbamic acid, which can undergo decomposition to give dimethylamine and carbon disulfide. In the second stage, several competitive transformations of these intermediates into the final products occur, viz., (1) the reactions of CS2 with primary amines on heating (70-110 deg C) yield mixed and symmetrical thioureas and the reactions of CS2 with secondary amines give symmetrical dithiocarbamates, and (2) insertion of CS2 into S-(thiocarbamoyl)thiohydroxylamines affords thiuram disulfides. Thiuram disulfides formed from primary amines decompose to give isothiocyanates, which are converted into thioureas by condensation with amines, whereas thiuram disulfides which are obtained in the reactions with secondary amines and which cannot form thioureas react with amines analogously to TMTD.

Thiocarbamoylation of amine-containing compounds 4. Reactions of tetramethylthiuram disulfide with aliphatic amines

Thiocarbamoylation of primary and secondary aliphatic amines with tetramethylthiuram disulfide in various solvents at different temperatures was studied. At 110 °C, the reactions with primary amines afforded mixed N,N-dimethyl-N′-alkyl(cycloalkyl)thiourea