27412-71-1

Upstream product

• 7713-79-3 3-phenyl-5-isoxazolone 
• 13047-12-6 5-phenylpyrazolidin-3-one 
• 64-17-5 ethanol 
• 27412-70-0 3-phenylprop-2-yne hydrazide 
• 7223-30-5 3-phenyl-propynoic acid amide 
• 3446-58-0 3-oxo-3-phenylpropanamide 
• 26880-33-1 ethyl 2-chloro-3-phenylacrylate 
• 59106-33-1 ethyl 2-bromo-3-phenylacrylate 
• 116519-41-6 ethyl β-ethoxycinnamate 
• 58756-33-5 3-phenyl-3-semicarbazono-propionic acid ethyl ester 
• 602-98-2 3-benzoyl-6-phenylpyran-2,4-dione 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 109592-72-5 3-phenyl-3-(1⁽²⁾H-pyrazole-3-carbonylhydrazono)-propionic acid ethyl ester 
• 2216-94-6 phenylpropynoic acid ethyl ester 

Downstream Products

• 79994-66-4 3-phenyl-1,2,4-trimethylpyrazolin-3-one 
• 13572-29-7 3-phenyl-4-phenylhydrazono-2-pyrazolin-5-one 
• 66076-96-8 (3-oxo-5-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-(5-oxo-3-phenyl-1,5-dihydro-pyrazol-4-ylidene)-methane 
• 32258-59-6 acetic acid-(5-phenyl-1⁽²⁾H-pyrazol-3-yl ester) 
• 39513-07-0 3-methoxy-5-phenyl-1⁽²⁾H-pyrazole 
• 80030-92-8 2-methyl-5-phenyl-2,3-dihydro-1H-pyrazol-3-one 
• 138023-92-4 4-(4-diethylamino-phenylimino)-5-phenyl-2,4-dihydro-pyrazol-3-one 
• 486-38-4 1,2-dimethyl-5-phenyl-1,2-dihydro-pyrazol-3-one 
• 66076-87-7 4,4-dibromo-3-phenyl-2-pyrazolin-5-one 
• 1688-32-0 4-oximino-3-phenyl-2-pyrazolin-5-one 

Relevant academic research and scientific papers

Synthesis and studies of a tetradecanuclear manganese(II)/(III) cage

A novel Mn14 cluster is reported; this is a new nuclearity for manganese cages and highly unusual in that the ligands are not exclusively oxygen donors.

Nickel-Catalyzed C-O Cross-Coupling Reaction at Low Catalytic Loading with Weak Base Participation

Herein, we report a nickel-catalyzed crossing-coupling reaction for the synthesis of diaryl ethers. The desired products are achieved by coupling heterocyclic alcohols with aryl bromides bearing strong electron withdrawing nitro group under the catalyst system of NiCl2(PPh3)2 and weak base KHCO3. This mild reaction exhibits a broad functional group tolerance. Compound 4 as an important intermediate is suitable for further structural modification of MALT1 inhibitor MI-2.

Hydrohydrazination of Arylalkynes Catalyzed by an Expanded Ring N-Heterocyclic Carbene (er-NHC) Gold Complex under Solvent-Free Conditions

[(THD-Dipp)AuOTf], supported by the strongly electron donating, sterically bulky THD-Dipp (1,3-bis(2,6-diisopropylphenyl)hexahydro-2H-1,3-diazepine-2-ylidene) seven-membered N-heterocyclic carbene ligand, efficiently promotes intermolecular addition of Ts- and Boc-hydrazine to arylalkynes under solvent-free conditions.

A rare γ-pyranopyrazole skeleton: Design, one-pot synthesis and computational study

Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straightforward synthetic route has been developed for a range of pyrazole fused γ-pyrone derivatives. The reaction mechanism proposed for the chemoselective form

Exploration of isosteric replacement of imidazolidinone motif in 4-phenyl-1-arylsul-fonylimidazolidinone with pyrazole and pyrazolidinone for cytotoxicity

To investigate the possible isosteric replacement of imidazolidinone moiety in 4-phenyl-1-arylsulfonyl-imidazolidinones (2) for broad and potent anti-cancer agents, a series of 5-phenyl-1H-pyrazol-3-yl 1-(acyl)indoline-5-sulfonates (4) and 1-(1-(acyl)indo

5-Iodo-3-ethoxypyrazoles: An entry point to new chemical entities

Our program, which has focused on the preparation of new pyrazole derivatives, has led us to report here an original and simplified preparation of ethyl 3-ethoxy-lW-pyrazole-4-carboxylate. This is based on the reaction of hydrazine monohydrochloride and diethyl 2-(ethoxymethylene)malonate. Further transformations of this key compound allowed the preparation of the two possible iodinated isomers, namely, 3-ethoxy-4-iodo- and 3-ethoxy-5-iodo-1H-pyrazole. These compounds have opened the way to a quick access to many original pyrazole series. As an illustration, we report here on the selectivity of N-arylation, by using the Lam and Cham method, the C4- and C5-arylation of some of these 3-ethoxy-pyrazole derivatives by using the Suzuki-Miyaura reaction, and C5-benzylation reactions by means of the Negishi reaction. This was followed by hydrolysis of the ethoxy group, which led to the corresponding pyrazol-3-one derivatives. As a conclusion of this work, we conducted an investigation into the regiochemistry of the condensation between diethyl 2-(ethoxymethylene) malonate and the hydrochloride salts of methyl, benzyl, or phenyl hydrazine.

A simple approach to pyrazol-3-ones via diazenes

An efficient entry into pyrazol-3-ones is described starting from propenoic acids that were first transformed into the corresponding hydrazides. Oxidation of the hydrazides gave the diazenes and the latter cyclized to pyrazol-3-ones on treatment with ZrCl4. The methoxycarbonyl protection of the N-1 of the pyrazolone derivatives was easily removed under mild reaction conditions.

Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs

Various substituted 1,5-diarylpyrazol-3-one derivatives were synthesized and screened for analgesic, anti-inflammatory activities, ulcerogenic potential and for their ability to release nitric oxide. Most compounds exhibited significant analgesic and anti

Phase-transfer catalyzed acylation of 5(3)-hydroxy-3(5)-substituted-1H- pyrazoles

PTC acylation of 5(3)-hydroxy-3(5)-substituted-1H-pyrazoles by different acyl halide reagents at 25°C in the presence of tetrabutylammonium bromide as catalyst has been investigated. This work is aiming to study the comparison of N-versus O- and C-acylati

Tautomerism-dependent ring construction of N-heterocyclic compounds from the reactions of 1-alkynyl fischer carbene complexes and substituted pyrazolinones

Four types of N-heterocyclic ring systems were successfully constructed from the reactions of 1-alkynyl Fischer carbene complexes (OC) 5M=C(OEt)C≡CPh (1) (M = Cr, W) and substituted pyrazolinones (2). Reactions of 1 with 3-methyl-2-pyrazolin-5-one (2a), 3-n-propyl-2- pyrazolin-5-one (2b), 3,4-dimethyl-2-pyrazolin-5-one (2c), 3,4-trimethylene-2- pyrazolin-5-one (2d), or 3,4-tetramethylene-2-pyrazolin-5-one (2e) generated three kinds of Fischer aminocarbene complexes (3-5), and reactions of 1 with phenyl-substituted pyrazolinones, i.e., 3-phenyl-2-pyrazolin-5-one (2f) and its tautomer 3-phenyl-3-pyrazolin-5-one (2g), gave Fischer alkoxycarbene complexes (6) as the major products and aminocarbene complexes of types 3-5 as the minor products. Multiple tautomerism of pyrazolinones is attributed to the versatile formation of N-heterocyclic Fischer carbene complexes. Oxidative demetalation of complexes 3-6 with pyridine N-oxide or m-chloroperoxybenzoic acid efficiently afforded organic carbonyl products, and thus, strongly fluorescent syn-mixed-bimanes were prepared. The present findings constitute an alternative new method to synthesize mixed bimanes and other novel N-heterocyclic compounds.