2746-36-3

Basic information

• Product Name: 1-phenyl-[1,2,4]triazolo[4,3-a]quinoline
• Synonyms: 1-phenyl-[1,2,4]triazolo[4,3-a]quinoline
• CAS NO: 2746-36-3
• Molecular Weight: 245.283
• Mol File: 2746-36-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-phenyl-[1,2,4]triazolo[4,3-a]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-[1,2,4]triazolo[4,3-a]quinoline(2746-36-3)
• EPA Substance Registry System: 1-phenyl-[1,2,4]triazolo[4,3-a]quinoline(2746-36-3)

Safety Data

• Hazardous Substances Data: 2746-36-3(Hazardous Substances Data)

Upstream product

• 15793-77-8 2-hydrazinoquinoline 
• 611-73-4 Benzoylformic acid 
• 91-22-5 quinoline 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 
• 100-52-7 benzaldehyde 
• 59635-52-8 N-(phenylsulfonyl)benzohydrazonoyl chloride 
• 76226-69-2 N-[1-Morpholin-4-yl-1-phenyl-meth-(Z)-ylidene]-N'-quinolin-2-yl-hydrazine 
• 76226-71-6 N-[1-Phenyl-1-piperidin-1-yl-meth-(Z)-ylidene]-N'-quinolin-2-yl-hydrazine 
• 101117-42-4 benzoic acid-(N'-[2]quinolyl-hydrazide) 
• 614-21-1 2-nitroacetophenone 

Relevant articles and documents

The Preparation of 3-Phenyltriazolopyridines and Their Benzologs from N-(Phenylsulfonyl)benzohydrazonoyl Chloride and Pyridines

3-Phenyltriazolopyridines were obtained in good yields from N'-benzenesulfonohydrazidates, generated from 2-unsubstituted pyridines and N-(phenylsulfonyl)benzohydrazonoyl chloride (2), by oxidation with chloranil.The reaction of quinoline and isoquinoline with 2 gave 1-phenyl-3-phenylsulfonyl-3,3a-dihydrotriazoloquinoline and 3-phenyl-1-phenylsulfonyl-1,10b-dihydrotriazoloisoquinoline respectively, both in good yields; they aromatized to the corresponding triazoles by the 1,2-elimination of benzenesulfinic acid on heating.

Electrochemical synthesis of 1,2,4-triazole-fused heterocycles

A reagent-free intramolecular dehydrogenative C-N cross-coupling reaction has been developed under mild electrolytic conditions. In this atom- and step-economical one-pot process, valuable 1,2,4-triazolo[4,3-a]pyridines and related heterocyclic compounds could be synthesized efficiently from commercially available aliphatic or (hetero)aromatic aldehydes and 2-hydrazinopyridines. Various functional groups are compatible with this metal- and oxidant-free protocol which can be carried out on a gram scale easily. This novel method was applied to the synthesis of one of the top-selling drugs Xanax and late stage functionalization for generating chemical diversity in biologically relevant lead molecules.

[1,2,4]-triazol [4,3-a] pyridines compound and synthesis method thereof

The invention discloses a [1,2,4]-triazol [4,3-a] pyridines compound and a synthesis method thereof. The compound has a structure general formula shown as the formula (I), wherein R1 is selected fromaryl and heterocyclic groups; R2 is selected from hydrogen, alkyl, alkoxy, halogen or aryl. According to the synthesis method, alpha-ketonic acid and 2-hydrazinopyridine are used as raw materials; KIis used as a catalyst; Na2CO3 is used as alkali; TBHP is used as an oxidizing agent; 1,4-dioxane is used as a solvent; after a series of serial connection cyclization and decarboxylation aromatization, the [1,2,4]-triazol [4,3-a] pyridines compound is obtained. The [1,2,4]-triazol [4,3-a] pyridines compound is prepared under the condition of no transition metal and has the advantages that the reaction is efficient and fast; the conditions are mild; the substrate is simple and can be easily obtained; the applicability is wide; the reaction time is short; the yield is high, and the like; meanwhile, the post treatment of the reaction is simple and convenient; the harm to experiment operators is reduced; the environment-friendly effect is achieved; the green chemical requirements are met.