27460-33-9Relevant academic research and scientific papers
Efficient, stereoselective synthesis of 24(s), 25-epoxycholesterol
Tomkinson, Nicholas C. O.,Willson, Timothy M.,Russel, Jonathon S.,Spencer, Thomas A.
, p. 9919 - 9923 (2007/10/03)
Efficient, stereoselective syntheses of 24(S), 25-epoxycholesterol (1) have been developed starting from cholenic acid (4) or stigmasterol (8), both featuring as the key step Sharpless asymmetric dihydroxylation of desmosterol acetate (2). This work permits preparation of gram quantities of 1 for further evaluation as a natural regulator of cholesterol metabolism, specifically, e.g., as a ligand for the LXRα. nuclear receptor.
Isotopically labeled vitamin D derivatives and processes for preparing same
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, (2008/06/13)
This invention relates to isotopically labeled vitamin D compounds, including radiolabeled vitamin D compounds of high specific activity, methods for their preparation, and novel intermediates in their synthesis. The radiolabeled vitamin D compounds are characterized by high specific activity (up to 160 Ci/mmol) with the process providing a facile and convenient method for synthesizing such compounds.
