27461-48-9

Upstream product

• 162118-38-9 (3S,4R,5R,6S)-3,4,5-tris(benzyloxy)-6-methyltetrahydro-2H-pyran-2-ol 
• 73-34-7 6-deoxy-L-galactose 
• 86-01-1 Guanosine 5'-triphosphate 
• 76946-04-8 perbenzyl fucosyl bromide 

Downstream Products

• 592529-63-0 2,2-bis(benzyloxymethyl)-1,3-bis-[O-β-D-galactopyranosyl-(1->4)-(2-amino-2-deoxy-3-O-α-L-fucopyranosyl-β-D-glucopyranosyloxy)]-propane butane 1N,4N'-dioyl amide 

Relevant academic research and scientific papers

Enzymatic Synthesis of Human Milk Fucosides α1,2-Fucosyl para-Lacto-N-Hexaose and its Isomeric Derivatives

Enzymatic synthesis of para-lacto-N-hexaose and its isomeric structures as well as those α1,2-fucosylated variants naturally occurring in human milk oligosaccharide (HMOs) was achieved using a sequential one-pot enzymatic system. Three glycosylation routes comprising bacterial glycosyltransferases and corresponding sugar-nucleotide-generating enzymes were developed to facilitate efficient production of extended type-1 and type-2 N-acetyllactosamine (LacNAc) backbones and hybrid chains. Further fucosylation efficiency of two α1,2-fucosyltransferases on both type-1 and type-2 chains of the hexasaccharide was investigated to achieve practical synthesis of the fucosylated glycans. The availability of structurally defined HMOs offers a practical approach for investigating future biological applications. (Figure presented.).