27463-42-9

Usage

Uses

Used in Pesticide Industry:
5-(3,4-DICHLOROPHENYL)CYCLOHEXANE-1,3-DIONE was used as a pesticide and insecticide for its effectiveness in controlling a variety of pests. It was applied in agriculture to protect crops from insects and other harmful organisms, as well as in residential settings to control termites and other household pests.
Used in Environmental Regulation:
Due to the bioaccumulation of 5-(3,4-DICHLOROPHENYL)CYCLOHEXANE-1,3-DIONE in the environment and its long-term exposure linked to health issues such as cancer, reproductive disorders, and neurological problems, its production and use have been restricted and regulated. This has led to the development of alternative, less harmful pesticides and insecticides, as well as increased efforts in environmental monitoring and remediation to mitigate the effects of this pollutant.

InChI:InChI=1/C12H10Cl2O2/c13-11-2-1-7(5-12(11)14)8-3-9(15)6-10(16)4-8/h1-2,5,8H,3-4,6H2

Upstream product

• 55420-70-7 (E)-4-(3,4-dichlorophenyl)but-3-en-2-one 
• 105-53-3 diethyl malonate 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 74546-02-4 4-(3,4-dichlorophenyl)-3-butene-2-one 

Downstream Products

• 144128-84-7 7,8-Dichloro-3-(3,4-dichloro-phenyl)-10-hydroxy-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 144128-95-0 7-Chloro-3-(3,4-dichloro-phenyl)-10-methyl-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 75618-33-6 7-chloro-3-(3,4-dichlorophenyl)-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione 
• 55988-20-0 3-(3,4-dichlorophenyl)-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione 

Relevant academic research and scientific papers

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.

7-Chloro-3-substituted aryl-3,4-dihydro-1,9(2H,10H) and 10 hydroxy acridinedioneimines having antimalarial activity

7-Chloro-3-substituted aryl-3,4-dihydro-1,9-(2H,1OH) and 10-hydroxy-acridinedioneimines and their pharmaceutically acceptable salts and a process for preparing them are disclosed and claimed. The compounds are useful in the treatment of protozoan diseases