27465-52-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Isopropylpropiophenone is used as a building block for the preparation of 2-arylpropionic CXC chemokine receptor 1 (CXCR1) ligands. These ligands act as novel noncompetitive CXCL8 inhibitors, which have potential applications in the treatment of various inflammatory and immune disorders. The compound's unique structure allows for the development of new drugs that can modulate the activity of CXCR1, thereby providing therapeutic benefits in conditions where this receptor plays a significant role.

InChI:InChI=1/C12H16O/c1-4-12(13)11-7-5-10(6-8-11)9(2)3/h5-9H,4H2,1-3H3

Upstream product

• 98-82-8 Isopropylbenzene 
• 79-03-8 propionyl chloride 

Downstream Products

• 22975-62-8 1-isopropyl-4-propyl-benzene 
• 820260-08-0 2-bromo-1-(4-isopropyl-phenyl)-propan-1-one 
• 4397-08-4 1-(4-isopropylphenyl)propan-1-ol 
• 1186309-71-6 5-[1-(4-isopropylphenyl)propylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1350476-86-6 (Z)-2-cyano-N-ethyl-3-(4-isopropylphenyl)pent-2-enamide 
• 1215949-66-8 2-amino-N-ethyl-4-(4-isopropylphenyl)-5-methylthiophene-3-carboxamide 
• 83121-36-2 p-isopropyl-propiophenone diethyl ketal 
• 78575-49-2 1-(4-Isopropyl-phenyl)-propane-1,2-dione dioxime 
• 78575-14-1 1-(4-Isopropyl-phenyl)-propan-1-one oxime 

Relevant academic research and scientific papers

Facile preparation of 5-alkyl-1-aryltetrazoles with arenes, acyl chlorides, hydroxylamine, and diphenylphosphoryl azide

Successive treatment of arenes with acyl chlorides and AlCl3, the addition of water and removal of solvent, the reaction with NH2OH?HCl and K2CO3, and the reaction with diphenylphosphoryl azide and DBU under warming conditions gave the corresponding 5-alkyl-1-aryltetrazoles efficiently in good to moderate yields. The present method is one-pot transformation of arenes into 5-alkyl-1-aryltetrazoles using the Friedel-Crafts acylation and the Beckmann rearrangement under transition-metal-free conditions.

KOtBu-Mediated Domino Isomerization and Functionalization of Aromatic Allylic Alcohols

Transition-metal- as well as ligand-free base-mediated domino isomerization and alkylation of allylic alcohols is presented. This protocol features the conversion of simple allylic alcohols into the corresponding ketones through isomerization in the presence of a simple base. Significantly, these in situ generated ketones subsequently undergo alkylation with styrenes as electrophiles, in a domino one-pot fashion, as an atom- and step-economical chemical process.

Method for synthesizing high-content cyclamen aldehyde spice

The invention discloses a method for synthesizing a high-content cyclamen aldehyde spice, and relates to the technical field of fine chemical engineering. Cumin and propionyl chloride are catalyzed by lewis acid to be subjected to an acylation reaction, and isopropyl benzene acetone is generated; then isopropyl benzene acetone and phosphorus oxychloride are subjected to an acylation reaction, and after distillation and purification, the product, ethyl alcohol, hydrogen and a catalyst are subjected to a hydrogenation reaction; after the reaction is completed, a cyclamen aldehyde crude product is subjected to flashing and fractionation, ethyl alcohol is recycled, and finally spice-grade cyclamen aldehyde is obtained. The content of ortho-position cyclamen aldehyde and cyclamen alcohol in cyclamen aldehyde is controlled to be below 0.5%, and therefore the final product is pure and soft in fragrance and meets the requirements of flavor blending of flavors and fragrances.

Synthetic method for cyclamen aldehyde precursor--p-isopropyl-beta-chloro-alpha-toluene acrolein

The invention discloses a synthetic method for a cyclamen aldehyde precursor--p-isopropyl-beta-chloro-alpha-toluene acrolein, and relates to the technical field of fine chemical industry. The synthetic method comprises the following steps: with cumene and

Industrial production method of cyclamen aldehyde precursor p-isopropylbenzaldehyde-beta-chloro-alpha methyl benzol acrolein

The invention discloses an industrial production method of cyclamen aldehyde precursor p-isopropylbenzaldehyde-beta-chloro-alpha methyl benzol acrolein, and relates to the technical field of fine chemical engineering. The method comprises the steps that c

NEW ANALOGS OF POLYSPHORIN AND USES THEREOF FOR TREATING OR PREVENTING MALARIA

The present invention discloses new analogs of polysphorin and their uses as antimalarial drugs which are highly effective in the hepatic phase of the disease. The present invention further discloses a new method for preparing these compounds.

Benzofurans as suppressors of neurodegeneration

A compound of the formula: wherein R1 and R2 each is H or a hydrocarbon group which may be substituted, or R1 and R2 form a 3- to 8-membered carbo or heterocyclic ring which may be substituted; R3 is H, a lower alkyl which may be substituted or an aromatic group which may be substituted; R4 is (1) an aromatic group which may be substituted, (2) an aliphatic hydrocarbon group substituted by an aromatic group which may be substituted, which hydrocarbon group may be further substituted or (3) an acyl; X and Y each is oxygen or sulfur which may be oxidized; and ring A is a benzene ring which may be further substituted, or a salt thereof, is useful for an agent for suppressing neurodegeneration.

2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors

The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2). (R)-Ketoprofen (1) was previously reported to be a potent and specific noncompetitive inhibitor of CXCLS-induced human PMNs chemotaxis. We report here molecular modeling studies showing a putative interaction site of 1 in the TM region of CXCR1. The binding model was confirmed by alanine scanning mutagenesis and photoaffinity labeling experiments. The molecular model driven medicinal chemistry optimization of 1 led to a new class of potent and specific inhibitors of CXCL8 biological activity. Among these, repertaxin (13) was selected as a clinical candidate drug for prevention of post-ischemia reperfusion injury.

PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS

An agent for promoting the proliferation or differentiation of a stem cell and/or neural progenitor cell, comprising a compound represented by Formula: wherein each of R1 and R2 is H, a hydrocarbon group or a heterocyclic group, or taken together with the adjacent carbon atom to form a ring, R3 is H, a hydrocarbon group or a heterocyclic group, W is a group represented by Formula: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R4 is an acyl group having an aliphatic hydrocarbon group, which is substituted by an aromatic group and may have a further substitutent, or aromatic group, R5 is H, C1-6 alkyl or acyl, R4c is an aromatic group, an aliphatic hydrocarbon group or acyl, and X is O or S; Y is O, S or NH, Ring C is an optionally substituted benzene ring, or a salt or prodrug thereof is provided.

Process for the preparation of dihydrocinnamaldehyde derivatives

There is disclosed a novel process for preparing a number of cinnamaldehyde derivatives. These cinnamaldehyde derivatives can be reduced to dihydrocinnamaldehyde derivatives, a number of which are commercially important in the preparation of fragrances. The invention is also directed to a number of novel intermediates and their preparation.