274677-77-9

Upstream product

• 103321-52-4 (S)-N-(fluoren-9-ylmethoxycarbonyl)prolyl chloride 
• 91200-21-4 (1S,3S)-methyl 1-phenyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-3-carboxylate 
• 93598-41-5 cis-1-phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl ester hydrochloride 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 73-22-3 L-Tryptophan 
• 4299-70-1 L-tryptophan methyl ester 
• 100-52-7 benzaldehyde 
• 19779-75-0 N_b-benzylidene-L-tryptophan methyl ester 

Relevant academic research and scientific papers

Synthesis of Indolyldiketopiperazines with NBS

Two series of indolyldiketopiperazines were synthesized starting from methyl 1-substituted-1,2,3,4-tetrahydro-β-carboline-3-carboxylate hydrochlorides via N-bromo-succinimide (NBS) as an important reagent. All eight compounds were characterized by nuclear

Enantioselective synthesis and antimicrobial activities of tetrahydro-β-carboline diketopiperazines

A series of single isomers tetrahydro-β-carboline diketopiperazines were stereoselectively synthesized starting from l-tryptophan methyl ester hydrochloride and six aldehydes through a four-step reaction including Pictet-Spengler reaction, crystallization-induced asymmetric transformations (CIAT), Schotten-Baumann reaction, and intramolecular ester amidation. The chemical structures were characterized by nuclear magnetic resonance (NMR) and elemental analysis, among which two compounds were determined by x-ray single crystal diffraction. Moreover, antimicrobial activities of all the compounds were also tested. Chirality 25:656-662, 2013. 2013 Wiley Periodicals, Inc.

Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues

Tryprostatin B and demethoxyfumitremorgin C are fungal inhibitors of mammalian cell cycle progression at the G2/M transition. N-Alkyl derivatives of the L-Trp-L-Pro diketopiperazine were prepared as analogues of tryprostatin B, and two of these