274901-13-2

Upstream product

• 108-24-7 acetic anhydride 
• 273402-79-2 [3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-2-oxo-cyclohexyl]-acetic acid tert-butyl ester 
• 74-95-3 1,1-dibromomethane 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 199613-48-4 5-tert-butyl-dimethylsilyloxy-(5S)-2-cyclohexenone 
• 273402-73-6 (2S,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,3-dihydroxy-cyclohexanone 
• 274901-11-0 [5-(tert-butyl-dimethyl-silanyloxy)-1,2,3-trihydroxy-cyclohexyl]-acetic acid tert-butyl ester 
• 273402-76-9 [3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1,2-dihydroxy-cyclohexyl]-acetic acid tert-butyl ester 

Downstream Products

• 81506-23-2 <3S-(1E,3α,5β)>-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic acid ethyl ester 
• 274901-14-3 [3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of 1 α,25-dihydroxyvitamin D3 A-ring precursor starting with 5-tert-butyldimethylsiloxy-2-cyclohexenone

The A-ring precursor of 1 α,25-dihydroxyvitamin D3 [(E)-4] has been prepared starting from the (5S)-tert-butyldimethylsiloxy-2-cyclohexenone [(S)-1] via eight steps in 19% overall yield, where a catalytic osmium dihydroxylation which sets the stereochemistry of the hydroxyl group at C1 and a regioselective protection of the hydroxy group as a TBS-ether are the key steps. (C) 2000 Elsevier Science Ltd.