274910-19-9

Usage

Uses

Used in Pharmaceutical Industry:
2,3-DIHYDRO-1,4-BENZODIOXIN-5-YLMETHANOL is utilized as a precursor in the synthesis of various pharmaceuticals, playing a crucial role in the development of new medications due to its unique chemical structure.
Used in Fine Chemicals Production:
It serves as an intermediate in the production of fine chemicals, contributing to the creation of high-quality specialty products within the chemical industry.
Used in Fragrance Industry:
2,3-DIHYDRO-1,4-BENZODIOXIN-5-YLMETHANOL is used as an intermediate in the production of fragrances, enhancing the scent profiles of various perfumes and scented products.
Used in Flavor Industry:
Similarly, in the flavor industry, it is employed as an intermediate to create unique taste profiles for food and beverage products, adding depth and complexity to their flavor compositions.
Used in Specialty Chemicals Production:
2,3-DIHYDRO-1,4-BENZODIOXIN-5-YLMETHANOL is also integral in the production of other specialty chemicals, where its properties are leveraged to achieve specific functional or performance characteristics in the final products.

InChI:InChI=1/C9H10O3/c10-6-7-2-1-3-8-9(7)12-5-4-11-8/h1-3,10H,4-6H2

Upstream product

• 29668-43-7 2,3-dihydro-benzo[1,4]dioxine-5-carbaldehyde 
• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 106-93-4 ethylene dibromide 
• 4442-53-9 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid 
• 261767-10-6 ethyl 1,4-benzodioxane-5-carboxylate 

Downstream Products

• 214894-89-0 5-(bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxine 
• 274910-20-2 2-(2,3-dihydro-1,4-benzodioxin-5-yl)acetic acid 
• 29668-43-7 2,3-dihydro-benzo[1,4]dioxine-5-carbaldehyde 
• 116939-11-8 monochlormethylbenzo-1,4-dioxane 

Relevant academic research and scientific papers

PYRANOQUINAZOLINE DERIVATIVES AND NAPHTHOPYRAN DERIVATIVES

[Problem] A problem is presented in that conventional photochromic compounds cannot be considered adequate in terms of the colorizing/decolorizing rate and durability, and the production process therefore has many steps. The present invention provides an industrially applicable photochromic compound that has both a rapid colorizing/decolorizing reaction and high durability and can also be synthesized at a low cost. [Solution] This compound is characterized in that etheric oxygen atoms are bonded to the carbon atoms at position 1 of a pyranoquinazoline (8H-pyrano[3,2-f]quinazoline) skeleton and position 10 of a naphthopyran (3H-naphtho[2,1-b]pyran) skeleton, said compound having photochromic properties and being a photochromic compound that has both a rapid colorizing/decolorizing reaction and high durability. Also provided is an industrially applicable photochromic compound that can be synthesized at a low cost.

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

Replacing the naphthalene C-unit of the anti-tuberculosis drug bedaquiline with a range of bicyclic heterocycles of widely differing lipophilicity gave analogs with a 4.5-fold range in clogP values. The biological results for these compounds indicate on average a lower clogP limit of about 5.0 in this series for retention of potent inhibitory activity (MIC90s) against M.tb in culture. Some of the compounds also showed a significant reduction in inhibition of hERG channel potassium current compared with bedaquiline, but there was no common structural feature that distinguished these.

ANTIBACTERIAL COMPOUNDS AND USES THEREOF

The present invention relates to compounds of formula (I) including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of tuberculosis.

Practical synthesis of biaryl colchicinoids containing 3′,4′- catechol ether-based A-rings via Suzuki cross-coupling with ligandless palladium in water

Eight new biaryl colchicinoids containing 3′,4′-methylene or benzodioxy ether bridges were synthesized. The key synthetic step employed a ligandless, aqueous Suzuki cross-coupling reaction catalyzed by Pd(OAc) 2 with tetrabutylammonium bromide (TBAB) and potassium carbonate (K2CO3). The biaryl Suzuki products were typically formed in 5-30min and always in less than 1h.

PURINE DERIVATIVES AS KINASE INHIBITORS

The present invention provides kinase inhibitors of Formula I.

Benzofuran derivatives, their preparation and use

The present invention relates to benzofuran derivatives having general Formula (I) wherein A is selected from (1), (2), (3), (4) wherein Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, Csu

N-ACYLAMINO ACID DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS

An N-acylamino acid derivative of the formula: STR1 wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.