27501-92-4

Basic information

• Product Name: 2-(2-Hydroxyphenyl)-4-thiazolecarboxylic acid methyl ester
• Synonyms: 2-(2-Hydroxyphenyl)-4-thiazolecarboxylic acid methyl ester;Aeruginoic acid methyl ester
• CAS NO: 27501-92-4
• Molecular Formula: C₁₁H₉NO₃S
• Molecular Weight: 235.26
• Mol File: 27501-92-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-Hydroxyphenyl)-4-thiazolecarboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Hydroxyphenyl)-4-thiazolecarboxylic acid methyl ester(27501-92-4)
• EPA Substance Registry System: 2-(2-Hydroxyphenyl)-4-thiazolecarboxylic acid methyl ester(27501-92-4)

Safety Data

• Hazardous Substances Data: 27501-92-4(Hazardous Substances Data)

Upstream product

• 115921-07-8 (R)-2-(2'-hydroxyphenyl)-4-methoxycarbonyl-4,5-dihydrothiazole 
• 611-20-1 salicylonitrile 

Downstream Products

• 828936-79-4 2'-(2-hydroxyphenyl)-2'-thiazole-4'-(N-methoxy-N-methyl)carboxamide 
• 83053-39-8 2'-(2-hydroxyphenyl)-2'-thiazole-4'-carboxaldehyde 
• 27501-91-3 2-(2-hydroxyphenyl)thiazole-4-carboxylic acid 

Relevant articles and documents

Synthesis and Investigation of the Abiotic Formation of Pyonitrins A-D

Pyonitrins A-D are recently isolated natural products from the insect-associated Pseudomonas protegens strain, which were isolated from complex fractions that exhibited antifungal activity via an in vivo murine candidiasis assay. Genomic studies of Pseudomonas protegens suggested that pyonitrins A-D are formed via a spontaneous nonenzymatic reaction between biosynthetic intermediates of two well-known natural products pyochelin and pyrrolnitrin. Herein we have accomplished the first biomimetic total synthesis of pyonitrins A-D in three steps and studied the nonenzymatic formation of the pyonitrins using 15N NMR spectroscopy.