2751-06-6Relevant academic research and scientific papers
Ligand-Controlled Regiodivergent Catalytic Amidation of Unactivated Secondary Alkyl Bromides
Tortajada, Andreu,Menezes Correia, Jose Tiago,Serrano, Eloisa,Monleón, Alicia,Tampieri, Alberto,Day, Craig S.,Juliá-Hernández, Francisco,Martin, Ruben
, p. 10223 - 10227 (2021/08/24)
A regiodivergent Ni-catalyzed amidation of unactivated secondary alkyl bromides is described. The site-selectivity of the amidation event is dictated by subtle differences on the ligand backbone, allowing introduction of the amide function at either the original sp3 carbon-halide bond or at distal sp3 C-H sites within an alkyl side-chain via chain-walking scenarios.
