275375-70-7

Upstream product

• 275376-01-7 [4-(5-chloro-2-methoxy-phenyl)-4-hydroxy-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-3-yl]-acetic acid methyl ester 
• 275376-00-6 N-[2-(5-chloro-2-methoxy-benzoyl)-4-trifluoromethyl-phenyl]-succinamic acid methyl ester 
• 221113-32-2 (2-amino-5-trifluoromethyl-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone 
• 96-48-0 4-butanolide 
• 568565-36-6 [4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-acetic acid methyl ester 

Downstream Products

• 275375-69-4 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-2(1H)-quinolinone 

Relevant academic research and scientific papers

4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction

Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-one derivatives were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal

A mild and efficient synthesis of 4-aryl-quinolin-2(1H)-ones via a tandem amidation/Knoevenagel condensation of 2-amino-benzophenones with esters or lactones

Using LiHMDS as the base, a tandem amidation/Knoevenagel condensation of 2-aminobenzophenones with α-methylene esters or lactones gives 4-aryl-quinolin-2(1H)-ones in 65-96% yield. This method is mild, highly efficient, and amenable to scaleup.

Preparation of 3-substituted-4-arylquinolin-2-one derivatives

The present invention relates to a process for the preparation of 3-substituted-4-arylquinolin-2-one derivatives from a substituted coumarin and using a photochemical cyclization method on a dihydrofuran intermediate.

3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS

The present invention provides novel 3-substituted-4-arylquinolin-2-one derivatives having the general formula wherein R, R 1, R 2, R 3, R 4, R 5, R 6 and R 7 are as defined herein, or a non-toxic pharmaceutically acceptable salt thereof which are modulators of the large conductance calcium-activated K + channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.