275375-69-4

Upstream product

• 275376-00-6 N-[2-(5-chloro-2-methoxy-benzoyl)-4-trifluoromethyl-phenyl]-succinamic acid methyl ester 
• 221113-32-2 (2-amino-5-trifluoromethyl-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone 
• 275375-70-7 4-(5-chloro-2-methoxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-2(1H)-quinolinone 
• 592479-28-2 4-(2-benzyloxy-5-chloro-phenyl)-3-(2-hydroxy-ethyl)-6-trifluoromethyl-1H-quinolin-2-one 
• 275376-03-9 [4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-acetic acid 
• 275376-01-7 [4-(5-chloro-2-methoxy-phenyl)-4-hydroxy-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-3-yl]-acetic acid methyl ester 
• 568565-36-6 [4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-acetic acid methyl ester 

Downstream Products

• 863225-72-3 3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one 
• 930780-16-8 4-(2-(allyloxy)-5-chlorophenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one 
• 721918-22-5 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate 
• 721918-21-4 2-(3-(2-(tert-butyldiphenylsilyloxy)ethyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydroquinolin-4-yl)-4-chlorophenyl acetate 
• 930780-25-9 C₂₂H₂₁ClF₃NO₅ 
• 930780-24-8 C₃₈H₃₉ClF₃NO₅Si 
• 930780-20-4 C₂₂H₁₉ClF₃NO₃ 
• 930780-19-1 3-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(5-chloro-2-hydroxy-3-(2-methylallyl)phenyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one 
• 930780-18-0 4-(3-allyl-5-chloro-2-hydroxyphenyl)-3-(2-(tert-butyldiphenylsilyloxy)ethyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one 
• 930780-17-9 3-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(5-chloro-2-(2-methylallyloxy)phenyl)-1-methyl-6-(trifluoromethyl)quinolin-2(1H)-one 

Relevant academic research and scientific papers

ATROPISOMERS OF 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES

Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives having the general formula wherein R, R?1?, R?2?, R?3?, R?4? and R?5?, are as defined herein, or a non-toxic pharmaceutically acceptable salt, solvate or prodrug thereof. The atropisomers can

A mild and efficient synthesis of 4-aryl-quinolin-2(1H)-ones via a tandem amidation/Knoevenagel condensation of 2-amino-benzophenones with esters or lactones

Using LiHMDS as the base, a tandem amidation/Knoevenagel condensation of 2-aminobenzophenones with α-methylene esters or lactones gives 4-aryl-quinolin-2(1H)-ones in 65-96% yield. This method is mild, highly efficient, and amenable to scaleup.

4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction

Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-one derivatives were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal

Selective removal of a benzyl protecting group in the presence of an aryl chloride under gaseous and transfer hydrogenolysis conditions

Selective removal of a benzyl protecting group in the presence of an aryl chloride using Pd/C under gaseous and transfer hydrogenolysis conditions is described. The addition of chloride salts to the debenzylation reaction provides excellent selectivity.

Preparation of 3-substituted-4-arylquinolin-2-one derivatives

The present invention relates to a process for the preparation of 3-substituted-4-arylquinolin-2-one derivatives from a substituted coumarin and using a photochemical cyclization method on a dihydrofuran intermediate.

3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS

The present invention provides novel 3-substituted-4-arylquinolin-2-one derivatives having the general formula wherein R, R 1, R 2, R 3, R 4, R 5, R 6 and R 7 are as defined herein, or a non-toxic pharmaceutically acceptable salt thereof which are modulators of the large conductance calcium-activated K + channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.